HAMBURG, Germany, Sept. 19, 2024 /PRNewswire/ — In a bold move that could redefine how retail investors engage with financial markets, NAGA has launched the world’s first fully integrated trading app within Telegram, tapping into the messaging platform’s 950 million-strong user base. This pioneering step positions NAGA as the first to offer seamless access to financial markets directly within Telegram’s App Center, setting the stage for substantial user growth and fresh revenue streams.

NAGA Breaks New Ground: Unveils First-Ever Trading App Integrated into Telegram Messenger

Branded as the "NAGA Everything Trading" app, the platform brings the full suite of NAGA’s SuperApp trading features into the heart of the Telegram ecosystem. Users can now onboard, complete KYC procedures, deposit funds, and trade over 4,000 assets — including Real Stocks and CFDs on Stocks, Crypto, Forex, Commodities, Indices — without ever leaving the app. The NAGA Everything App is available directly through Telegram at https://t.me/nagatrading_bot.

Telegram’s highly active monthly user base can now enjoy frictionless access to global markets, all from within their familiar messenger interface. For NAGA, this integration is more than just an innovative feature; it’s a gateway to a massive, previously untapped audience. What makes this even more appealing is the built-in access to both mobile and web versions of NAGA’s platform, offering users a fully interconnected experience across devices.

Looking ahead, NAGA is planning monthly updates for the Telegram version of the app, with an upcoming release set to feature its hugely popular Social Trading with AutoCopy, enabling users to replicate the trades of top investors in real-time.

To celebrate the launch, NAGA is introducing a new promotion for non-EU residents only – new users registering on Telegram NAGA App can claim a $35 trading bonus just for signing up and verifying their account—no deposit required. This exclusive, time-limited offer is designed to give first-time traders a head start in exploring the new Telegram Everything Trading App. With only 1,000 spots available and a 7-day window to claim, it’s a fast-track opportunity to dive into trading and explore the markets. Stay tuned for more exclusive offers! This $35 bonus is the first of many exciting promotions NAGA has in store to celebrate the launch of their groundbreaking new app.

"A Game-Changing Milestone"

Octavian Patrascu, CEO of The NAGA Group AG, underscored the strategic significance of this launch: "Bringing the first-ever integrated trading app to Telegram is not just a breakthrough for NAGA, it’s a transformational moment for our industry. With access to nearly one billion users, we now have an unprecedented opportunity to democratize financial markets on a scale that was once unimaginable. This is a crucial step in our mission to make trading accessible to everyone while accelerating our business growth."

This move positions NAGA as an innovator in the rapidly evolving fintech space, with an eye firmly on global expansion. As traditional financial institutions grapple with digital transformation, NAGA is making bold strides toward capturing a new generation of traders who prefer intuitive, on-the-go access to financial markets — without the hassle of switching between apps.

About NAGA

NAGA is a forward-thinking fintech company revolutionising personal finance and trading with its all-in-one social trading platform. From Real Stocks and CFDs on Stocks, Crypto, Forex, Commodities, Indices and more to a physical VISA card, NAGA provides a complete, connected financial solution. With its innovative Autocopy features and a thriving community of traders, NAGA empowers users to trade, invest and collaborate and share ideas — making the markets accessible to all.

Ready to trade? Experience seamless trading like never before. Sign up and trade using the NAGA Everything Trading App now and take control of your investments in real-time https://t.me/nagatrading_bot .

Don’t miss out — trade smarter, trade faster, trade with NAGA.

Source : NAGA Breaks New Ground: Unveils First-Ever Trading App Integrated into Telegram Messenger

>

This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network

EAST RUTHERFORD, N.J., Sept. 19, 2024 /PRNewswire/ — Cambrex, a leading global contract development and manufacturing organization (CDMO), today announced that Snapdragon Chemistry, a Cambrex company, has successfully developed a new liquid-phase peptide synthesis (LPPS) technology that utilizes traditional active pharmaceutical ingredient (API) batch reactors and continuous flow, obviating the dependency on specialized, solid-phase reactors. This new LPPS technology materially reduces solvent demand and the need for excess reagents compared to standard solid-state peptide synthesis processes.

"Over the past several years, we have made significant investments in the research and development of complex synthetics, specifically to reduce the economic and environmental impacts of manufacturing peptides and oligonucleotides," said Dr. Matt Bio, Chief Scientific Officer, Cambrex. "Our new LPPS technology provides a significantly more cost-efficient and environmentally sustainable solution when compared to traditional solid-phase peptide synthesis, substantially reducing solvent usage and allowing the substitution of sustainable solvents."

The LPPS technology supports peptides up to 12 residues long, while larger peptides are then assembled in liquid phase, using a convergent fragment coupling approach. Processes developed with Cambrex’s LPPS technology can be scaled in the same way as traditional small molecules.

In addition to the LPPS, Cambrex also developed unique capabilities in peptide and protein crystallization, including a crystallization screening platform specifically for the discovery of crystalline forms of peptides and proteins. Crystallization can deliver improved product quality and stability and reduce the need for time-consuming preparative chromatography and lyophilization.

"With the clinical and commercial successes of peptide-based therapies, it’s imperative that we provide industry-leading solutions to develop and scale peptide candidates," said Thomas Loewald, CEO at Cambrex.

Cambrex will continue to invest in R&D across complex synthetic modalities, including further technology development for peptides, as well as new research on the application of artificial intelligence for the optimization of oligonucleotide processes.

About Snapdragon Chemistry
Snapdragon Chemistry, a Cambrex company, specializes in active pharmaceutical ingredient (API) batch and continuous flow process development, utilizing state-of-the-art automation technology and proprietary equipment to solve complex process and analytical development challenges. With R&D and manufacturing headquartered in Waltham, Massachusetts, Snapdragon’s 70+ employees come with strong ties to the local scientific community, with 31 PhD scientists on staff.

About Cambrex
Cambrex is a leading global contract development and manufacturing organization (CDMO) that provides drug substance development and manufacturing across the entire drug lifecycle, as well as comprehensive analytical and IND enabling services.

With over 40 years of experience and a team of 2,000 experts servicing global clients from North America and Europe, Cambrex offers a range of specialized drug substance technologies and capabilities, including continuous flow, controlled substances, solid-state science, material characterization, and highly potent APIs. 

Source : Cambrex Announces New Liquid-Phase Peptide Synthesis Manufacturing Technology

>

This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network

DUBAI, UAE, Sept. 19, 2024 /PRNewswire/ — Bybit, the world’s second-largest cryptocurrency exchange by trading volume, is proud to announce its sponsorship of the first-ever Ethereum Protocol "Attackathon."

This global audit contest and hackathon, organized by Immunefi in collaboration with the Ethereum Foundation, aims to bolster the security of the Ethereum protocol while nurturing its Public Good initiatives. Bybit’s sponsorship of 75 ETH, the largest contribution to date, reinforces its commitment to the growth and security of the Web3 landscape.

"At Bybit, we believe in the power of community and innovation to drive the future of blockchain technology," said Ben Zhou, co-founder and CEO of Bybit. "Our sponsorship of the Ethereum Attackathon aligns with our mission to support the security and sustainability of the ecosystems vital to the global crypto community. By contributing to this event, we’re investing in a safer and more resilient Ethereum network."

Bybit Sponsorships Support Innovation

Bybit has a proud tradition of elevating the crypto space, and this year is no exception. In 2023, we sponsored initiatives like the Dubai Multi Commodity Centre’s efforts to help crypto startups flourish. Now, with the World Series of Trading ("WSOT"), it is pushing the boundaries even further. With an unprecedented $10,000,000 prize pool, WSOT 2024 is the ultimate convergence of centralized and decentralized trading, offering participants a chance to "Ride the Best DEX and CEX Waves to Glory".

Through these initiatives, Bybit is also actively nurturing the next generation of Web3 builders, investing in a future where blockchain technology can thrive. Bybit’s contribution to the WSOT provides prize money and opens doors for builders and developers to receive ongoing support, mentorship, and resources from the crypto industry’s key players.

Ethereum Protocol Attackathon: Enhancing Security Through Collaboration

The Ethereum Protocol Attackathon is a groundbreaking event designed to enhance the security of the Ethereum protocol via a large-scale, crowdsourced security audit. Hosted by Immunefi, this eight-week event will gather the brightest minds in the Ethereum community to assess the protocol’s code.

Bybit’s contribution of 75 ETH to the Attackathon’s reward pool underscores its commitment to the Ethereum ecosystem and its broader goal of fostering a secure, decentralized future. Thanks to contributions from various industry leaders, including the Ethereum Foundation’s initial $500,000 USD seed, the Attackathon is expected to raise over $2 million USD for its reward pool.

#Bybit / #TheCryptoArk / #WSOT2024

About Bybit

Bybit is the world’s second-largest cryptocurrency exchange by trading volume, serving over 40 million users. Established in 2018, Bybit provides a professional platform where crypto investors and traders can find an ultra-fast matching engine, 24/7 customer service, and multilingual community support. Bybit is a proud partner of Formula One’s reigning Constructors’ and Drivers’ champions: the Oracle Red Bull Racing team.

For more details about Bybit, please visit Bybit Press.
For media inquiries, please contact: [email protected]
For more information, please visit: https://www.bybit.com
For updates, please follow: Bybit’s Communities and Social Media

Discord | Facebook | Instagram | LinkedIn | Reddit | Telegram | TikTok | X | Youtube

Source : Bybit Collaborates with Ethereum's First Attackathon as a Unicorn Sponsor, Expands WSOT 2024 Prize Pool

>

This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network

MONTRÉAL, Sept. 19, 2024 /PRNewswire/ — The law firm FAGUY & CO. BARRISTERS AND SOLICITORS INC. announces that, on May 24th, 2024, the Superior Court of Québec authorized a securities class action to proceed against Bombardier Inc. and its former CEO and CFO, Alain Bellemare and John Di Bert, in Court File No. 500-06-000977-195. The merits of the claims in the class action, or the allegations of fact on which the claims are based, have not been proven or determined by the Court. The defendants dispute the claims asserted against them and deny any allegation of wrongdoing made by the plaintiff in the class action.

The class action is brought on behalf of all persons and entities who acquired or purchased Bombardier’s securities during the period spanning from August 2, 2018 to November 8, 2018, inclusively, and held all or some of these securities until November 8, 2018. You are a member of the class action if you meet this description.

The class action asserts that Bombardier released documents containing false and misleading information relating to its 2018 free cash flow guidance. It is alleged that when the misrepresentations and omissions of fact were publicly corrected, Bombardier’s securities dropped significantly in value causing the class members damages.

Details on the authorization of the class action, including the process for class members to opt-out of the class action, no later than October 31, 2024, are available at: www.faguyco.com/bombardier-notice.

The judgment of the Superior Court of Québec, and information about the class action in English and French, are available on class counsel’s website at: https://www.faguyco.com/class-actions/bombardier.

Information on the class action can also be found on the website of the Québec Registry of class actions at: https://www.registredesactionscollectives.quebec/en.

For any inquiries, please contact class counsel acting on behalf of the representative plaintiff and the class members:

FAGUY & CO. BARRISTERS AND SOLICITORS INC.,
329 de la Commune Street West, suite 200,
Montréal (Québec) H2Y 2E1
Tel: 514.285.8100 ext. 225
Fax: 514.285.8050, 
[email protected]

Source : The Superior Court of Québec authorizes a securities class action against Bombardier Inc. and its former CEO and CFO

>

This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network

Securing Top 5 Position in over 20 Key Markets

HONG KONG, Sept. 19, 2024 /PRNewswire/ — Infinix, a trendy tech brand crafted for young consumers, continues its upward trajectory with a fifth consecutive quarter of year-over-year growth. According to IDC’s Worldwide Quarterly Mobile Phone Tracker, Infinix marked an 18.8 % increase in global smartphone shipments in Q2 2024 compared to the same period last year, further solidifying the brand’s growing influence in global markets.

Infinix Achieves 5 Consecutive Quarters of Positive YoY Growth in Global Smartphone Shipment

"Infinix’s exceptional performance in Q2 2024 underscores our relentless pursuit of innovation and our deep understanding of consumer needs globally. We will continue to raise the bar with our products and services, engage in meaningful conversations with consumers, and advance technological innovation to fulfill our commitment to empowering the youth," Tony Zhao, General Manager at Infinix.

Consistent Impressive Growth

Infinix’s growth continues to impress, securing top 5 market share positions in over 20 key markets globally. The brand has maintained its No. 1 position in strongholds like the Philippines and Pakistan, while high-growth regions such as Malaysia, Indonesia, Algeria, and Saudi Arabia have reported year-over-year shipment increases ranging from 50% to an astounding 469% in Q2 2024.

This sustained momentum is driven by Infinix’s consistent delivery of innovative products and its dynamic engagement with consumers. In the first half of 2024, the brand launched the feature-packed NOTE 40 series, featuring the brand’s first proprietary Cheetah X1 chip, breakthrough All-Round FastCharge 2.0, and Infinix MagKit to deliver a seamless 24/7 user experience. Additionally, Infinix collaborated with BMW Group Designworks to create a sleek, high-end Racing Edition smartphone that’s as stylish as powerful.

Infinix’s GT 20 Pro gaming smartphone set a new standard as the first in its price segment to feature a dedicated gaming display chip. This advancement placed the GT 20 Pro among the world’s first patch of smartphones to support PUBG Mobile and Honor of Kings at 120FPS. Building on its technological innovations, Infinix has partnered with popular game IPs and major esports events like PMSL, PMWC, MAL, MDL. Additionally, by organizing gaming tournaments, Infinix has further solidified its strong connection with mobile gaming enthusiasts.

Underscoring its commitment to empowering younger generations, Infinix’s dedication to innovation extends beyond products to impactful social initiatives. As a responsible global player, Infinix collaborates with UNESCO and Google to provide AI and robotics education to teenagers through CogLabs workshops. The brand has also forged strategic partnerships with MediaTek and Honor of Kings to push the boundaries of mobile gaming technology. Furthermore, in collaboration with Samsung’s System LSI Business, Infinix introduced industry-leading features, including the world’s first 108MP AI-powered deep learning algorithms.

These innovations and social initiatives have earned Infinix recognition as the sixth most innovative brand in the Asia-Pacific region by Fast Company and in the Top 50 Kantar BrandZ Chinese Global Brand Builders 2024. Leveraging its robust market growth and brand development, Infinix is committed to focusing on technology and product innovation to empower the youth globally.

About Infinix:

Founded in 2013, Infinix is a trendy tech brand crafted for young consumers. With a presence in over 70 countries and regions, Infinix delivers cutting-edge technology, stylish design, and outstanding performance. Our product lineup includes smartphones, TWS earbuds, smartwatches, laptops, and smart TVs. In 2023, Infinix was recognized in Kantar and Google’s top 50 Chinese Global Brand Builders Report and ranked sixth in Fast Company’s World’s Most Innovative Companies of 2024 in the Asia-Pacific sector.

For more information, please visit: http://www.infinixmobility.com/

Source : Infinix Achieves 5 Consecutive Quarters of Positive YoY Growth in Global Smartphone Shipment with 18.8% YoY Increase in Q2 2024

>

This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network

Mark your calendar, Singapore! The Singapore River Festival gears up for its 8th edition, promising even more excitement and vibrant celebrations along the river.

SINGAPORE, Sept. 19, 2024 /PRNewswire/ — Experience the splendour of Singapore River Festival 2024! This year, ‘Lights and Colours’ is back bigger and brighter, as the river bursts into life with a breathtaking display. Enjoy an exciting lineup of events, including enchanting light shows on iconic bridges, captivating music performances on river cruise, fun-filled pet-friendly activities, engaging heritage games, and mesmerising night walks. From 4th to 13th October, join us in celebrating the rich heritage and diversity of food and entertainment at the heart of Singapore, creating unforgettable memories along the historic river. 

Mark your calendar, Singapore! The Singapore River Festival gears up for its 8th edition, promising even more excitement and vibrant celebrations along the river.

Themed ‘River of Lights and Colours,’ this highly-anticipated festival once again brings the heritage bridges to life with dazzling light shows. Visitors are also invited to explore Singapore’s rich history and culture, savour local dishes, participate in cocktail-making and food workshops, and enjoy a variety of family-friendly events around Boat Quay, Clarke Quay, and Robertson Quay.

"As we kickstart this year’s Singapore River Festival, we celebrate our commitment to creating a space where every visitor feels welcomed. This festival is a fantastic opportunity to bring people together at the heart of Singapore, where food, entertainment, and the lively atmosphere create memorable experiences. We’re thrilled to see more visitors spending time along the Singapore River, enjoying everything this vibrant area has to offer. To further this commitment, our vision for the continued development of the Singapore River area includes collaborating with partners to support local businesses and boost the precinct’s vibrancy, ensuring a thriving and dynamic community for years to come," said Michelle Koh, Executive Director, Singapore River One.

"The Singapore River has always been central to Singapore’s history and development, serving as the lifeline of Singapore’s trade and commerce in its early years. Today, it has transformed into a thriving hub of activity – with historic buildings, commercial activities and culture, as well as pedestrian-friendly waterfronts and promenades. Its progress reflects the close collaboration between our public and private sectors. As we gather for the 8th edition of the Singapore River Festival, we celebrate not just the river’s rich heritage but the shared efforts that have driven its development and fueled economic growth," said Associate Professor Muhammad Faishal Ibrahim, Minister of State for Home Affairs & National Development.

Festival Highlights: A Feast for the Senses (4th to 13th October)

Symphony of Lights: Cavenagh Bridge, Read Bridge, and Alkaff Bridge come alive with themed light shows. Visitors will be treated to an audio-visual extravaganza as the lights move in harmony with captivating music. These displays illuminate Singapore’s cityscape along the river, showcasing the city’s dynamic energy, diverse food and entertainment, and serene beauty.

Cavenagh Bridge features "Urban Pulse", celebrating Singapore’s vibrant energy by showcasing dynamic lights that sync with the city’s rhythm. This display illuminates the historical charm of the bridge and the thriving city hub, enhancing the lively riverside atmosphere, inviting everyone to enjoy the vibrant ambience. Read Bridge presents "Eclectic Tapestry" that showcases Singapore’s diverse food and entertainment scene with a lively blend of lights and sounds. The light projection weaves a captivating display, creating a tapestry of excitement and enjoyment. Alkaff Bridge showcases "Tranquil Oasis" to project serene, calming lights that envelop the area in peaceful hues. This display mirrors the nearby greenery and tranquil waters, offering a calming retreat amidst the urban bustle.

Singapore River Signatures (SRS): Food lovers are also in for a treat with this event that celebrates the culinary diversity along the rivers — where they can uncover hidden gems through a specially-curated food tour, join engaging workshops and masterclasses and enjoy special promotions.

One of the key activities is the Taste of the Quays tour where the participants can enjoy food hopping and taste local delights from heritage and young brands such as Fu Lin’s Signature Yong Tau Foo, Rendezvous Hock Lock Kee’s Nasi Padang, and nut-based gelato from Dopa Dopa. They can also decorate their own croissants at the artisanal bakery, Kwaasong Bakeshop.                                                                                                         

An Even More Exciting Line-Up of Activities for All

Rhythmic Symphony 

Catch the Rhythmic Symphony to enjoy captivating live music performances both on river cruise and along the waterfront. This unique musical experience offers a delightful blend of sights and sounds, creating an enchanting atmosphere for all to enjoy. Whether you’re strolling along the waterfront or cruising on the boat, let the symphony transport you to a world of harmony and rhythm.

Date:

:

4th – 5th October

Time:

:

7.15pm to 10pm

Location:

:

Boat Quay, Waterfront Promenade

City Light Walk 

Join us for a fun night walk to experience the enchanting nightscape and discover historical fun facts of the Singapore River! Enjoy glowing figurines, interactive photo booths, fun workshops, and exclusive merchandise.

Date:

:

5th October

Time:

:

6pm (for 7km walk)
7pm (for 3km walk)

Location:

:

Clarke Quay Central

Fur-tastic Paw-ty 

For pet owners and lovers, the Fur-tastic Paw-ty is the perfect chance to hang out with your furry friends and enjoy fun activities, including bumboat rides with pets operated by Singapore River Cruise, pet obstacle courses, and fun challenges. You can also join pet food workshops, snap photos at cute photo booths, and explore the pet market.

Date:

:

12th – 13th October

Time:

:

12 to 10pm

Location:

:

CQ @ Clarke Quay

Heritage Games Fiesta 

Visitors can further relive the nostalgia with giant traditional games like pick-up sticks, snakes and ladders, and aeroplane chess. Additionally, enjoy engaging workshops like ‘Make a Chapteh’ and ‘Paint a Wooden Top’, movie screening, and delightful giveaways like balloon sculptures and candy floss.

Date:

:

12th – 13th October

Time:

:

2 – 8pm (for 12 Oct)
2 – 6pm (for 13 Oct)

Location:

:

Robertson Walk

The Singapore River Festival is made possible by BlueSG (a member of Goldbell), City Energy, Clarke Quay Central, CQ @ Clarke Quay, GoRental, Hong Leong Holdings, Mitsubishi Electric, Riverside Point, and Robertson Walk. This festival is supported by Unearthed Productions, Event Partner, and Water B, Boat Partner.

Join us for the celebration of this annual event with exclusive activities for families, friends, and even furry companions this October.

For the latest updates and event details about Singapore River Festival 2024, visit www.srf.sg.

About Singapore River One

Singapore River One (SRO) is a private sector-led partnership charged with the day-to-day management, maintenance, enhancement and marketing of the Singapore River. SRO is the first pilot Business Improvement District (BID) and is a not-for-profit company with a singular focus on leveraging public and private investments, increasing footfall, and enhancing property values within the Singapore River precinct.

SRO is responsible for the place management of the Singapore River precinct – including Boat Quay, Clarke Quay and Robertson Quay. It is the intent of SRO that the river be managed as one precinct – one destination – with specialised programs and service delivery methods utilised in each quay as needed, and as directed by a 4-year business plan. New partnership initiatives will leverage and pool resources from a variety of public and private sector sources; it will have the involvement and participation of both public and private sector stakeholders, and it will be empowered with the role of implementing the business plan and place managing the Singapore River precinct.

Source : A Dazzling Spectacle: Singapore River Festival Celebrates 8th Edition with 'River of Lights and Colours'

>

This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network

BEIJING, Sept. 19, 2024 /PRNewswire/ — An overseas media team consisting of 10-odd chief editors and journalists from countries such as Kazakhstan, Sri Lanka, Spain, and Romania immersed themselves in Yulin culture during their visit to Yulin City in northwest China’s Shaanxi Province from September 12 to 14.

The media professionals visited Northern Shaanxi Folk Song Museum, the largest cultural and industrial development center for northern Shaanxi folk songs in China. Through six specialized exhibition areas, they gained a comprehensive understanding of the history and current development of folk songs in northern Shaanxi. Distinctive live performances and 5D cinema offered the media team an immersive experience of the charming northern Shaanxi folk songs.

Through music, culture can be passed down from generation to generation, said Serik Korzhumbayev, editor-in-chief of Delovoy Kazakhstan, adding that he felt the spirit of people in northern Shaanxi and the regional culture through the singers’ voice and beautiful melody.

At the intangible cultural heritage exhibition hall in Yulin’s Yuyang District, overseas media friends learned paper-cutting. Isaura Diez Millan, chief correspondent of Latin American News Agency in China, said the exhibition hall is interesting. It helps visitors have a deeper understanding of Yulin’s intangible cultural heritage and promote mutual understanding and respect among different civilizations.

The team also visited Shimao Museum in Shenmu City under the jurisdiction of Yulin. The museum is dedicated to the culture of Shimao, which is an archaeological site with a stone-built city dating back approximately 4,000 years.

A large number of artifacts unearthed at the Shimao site and those from the same period, including jade, stoneware, pottery, bone tools, stone carvings and colorful murals, were displayed in the museum, enchanting the overseas media practitioners.

Marveled at the Shimao civilization, Yasiru Bandara Ranaraja, founder and director of Belt & Road Initiative Sri Lanka, said the exhibits were a testament to the existence of a highly prosperous group of people about 4,000 years ago, who not only mastered advanced farming and hunting techniques, but also had profound cultural and religious heritage. The excavation and protection of Shimao relics have set an good example, ensuring the pass-down of the precious cultural heritage and having a profound impact on China and even the whole world.

Original link: https://en.imsilkroad.com/p/342192.html

Source : Xinhua Silk Road: Overseas media professionals immerse themselves in NW. China's Yulin culture

>

This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network

HONG KONG, GERMANTOWN, Md., and SUZHOU, China, Sept. 19, 2024 /PRNewswire/ — Sirnaomics Ltd. (the "Company", Stock Code: 2257, together with its subsidiaries, the "Group" or "Sirnaomics"), a leading biopharmaceutical company engaging in discovery and development of advanced RNAi therapeutics, today announced that the company in collaboration with Dr. Mark Nestor’s team from the Center for Clinical and Cosmetic Research in Miami Florida has jointly published a major breakthrough for its novel siRNA therapeutics revealing a novel mechanism of action of a significant reduction of adipose tissue in preclinical animal models. This groundbreaking work entitled "Novel injectable polypeptide nanoparticle encapsulated siRNA targeting TGF-β1 and COX-2 for localized fat reduction I: Preclinical in vitro and animal models", published at Journal of Cosmetic Dermatology, 2024; 00:1-11, creates a solid foundation for the Company’s RNAi-based therapeutic program for focal fat reduction treatment.

The study evaluates the efficacy of STP705, an injectable containing siRNA encapsulated within histidine-lysine polypeptide (HKP) nanoparticles targeting transforming growth factor β1 (TGF- β1) and cyclooxygenase-2 (COX-2), crucial mediators in adipocyte differentiation and fat retention, using in vitro experiments on mouse preadipocytes and in vivo trials using Diet Induced Obese (DIO) mice and Yucatan minipigs. The study results indicated that STP705 effectively reduced the expression of TGF-β1 and COX-2, with a notable decrease in adipocyte volume and lipid content without apparent adverse systemic effects. In DIO mice, the HKP- siRNA complex demonstrated precise localization to injected adipose tissue, maintaining significant gene silencing, and detectable levels of siRNA for up to 14 days post-administration. The data in minipigs showed a significant reduction in subcutaneous adipose tissue thickness up to 56 days post-administration. In conclusion: These studies support the use of targeted-siRNA therapy specifically targeting TGF-β1 and COX-2, for localized fat reduction, offering a potential minimally invasive alternative to current fat reduction methods.

Mark S. Nestor, M.D., Ph.D., a recognized world expert in clinical research in clinical Dermatology and aesthetics, who is a Voluntary Professor at the Department of Dermatology and Cutaneous Surgery and the Department of Surgery, Division of Plastic Surgery at the University of Miami, Miller School of Medicine and serves as Director of the Center for Clinical and Cosmetic Research™ and the Center for Cosmetic Enhancement®, Aventura, Florida, is the senior author of this publication; he comments: "The results of all of the pre-clinical studies clearly indicate the significant potential of STP705 to use as a safe and effective method of reducing localized fat accumulation and sets the stage for the clinical pathway for this indication."

Dr. Patrick Lu, the founder, Chairman and CEO of Sirnaomics, comments, "The latest publication indicated that Sirnaomics’ leading drug candidate, STP705, has exhibited a novel mechanism of action, by specifically silencing TGF-β1 and COX-2 in the subdermal adipose tissue, resulted in localized fat reduction.  The preclinical studies not only showed that It is safe and very well-tolerated, but also achieved preliminary efficacy in inducing adipocyte apoptosis and tissue remodeling, suggesting a safer alternative or adjunct to existing fat reduction therapies."

About Sirnaomics

Sirnaomics is an RNA therapeutics biopharmaceutical company that focuses on the discovery and development of Sirnaomics is an RNA therapeutics biopharmaceutical company with product candidates in preclinical and clinical stages that focuses on the discovery and development of innovative drugs for indications with medical needs and large market opportunities. Sirnaomics is the first clinical-stage RNA therapeutics company to have a strong presence in both Asia and the United States. Based on its proprietary delivery technologies: Polypeptide Nanoparticle Formulation and the 2nd generation of GalNAc conjugation, the Group has established an enriched drug candidate pipeline. Sirnaomics is currently holding a leadership position on advancing RNAi therapeutics for oncology application with multiple successes of its clinical programs for STP705 (Phase IIa, IIb) and STP707 (Phase I). The ongoing Phase I study of STP122G represents the first drug candidate of GalAhead™ technology entering clinical development with an encouraging therapeutic efficacy and safety readouts. Learn more at: www.sirnaomics.com.

Source : Sirnaomics Announces Demonstration of a Novel Mechanism of Action of Its siRNA Therapeutics for Focal Fat Reduction in Journal of Cosmetic Dermatology

>

This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network