SHANGHAI, Dec. 12, 2023 /PRNewswire/ — CARsgen Therapeutics Holdings Limited (Stock Code: 2171.HK), a company focused on innovative CAR T-cell therapies for the treatment of hematologic malignancies and solid tumors, announces that at the 2023 American Society of Hematology ("ASH") Annual Meeting, the Company presented one poster with study results for zevorcabtagene autoleucel ("zevor-cel", R&D code: CT053, an autologous CAR T-cell therapy candidate against BCMA), which include the 3-year follow-up on efficacy and safety results from the Phase I portion of Phase I/II registrational study in China (LUMMICAR-1, NCT03975907). Details are listed below:

Poster #4845: Three-Year Follow-up on Efficacy and Safety Results from Phase I LUMMICAR Study 1 of Zevorcabtagene Autoleucel in Chinese Patients with Relapsed or Refractory Multiple Myeloma

Zevor-cel is a fully human autologous chimeric antigen receptor (CAR) T-cell therapy product against B-cell maturation antigen (BCMA) which is being developed for the treatment of patients with relapsed or refractory multiple myeloma (R/R MM).

The LUMMICAR STUDY 1 trial is a multi-center, open-label Phase I/II clinical trial ongoing in China. The New Drug Application (NDA) in China for zevor-cel is based on the Phase I/II data from LUMMICAR STUDY 1 and is currently under review.

Herein, the Company presented the updated results with 3 years of follow-up after the last patient was infused with zevor-cel in the Phase I portion of the study. Responses were assessed by investigator per the International Myeloma Working Group (IMWG) 2016 criteria.

As of July 17, 2023, 14 participants with R/R MM, who had received at least 3 prior regimens including a proteasome inhibitor and an immunomodulatory drug (IMiD) with a median of 6 prior regimens (range: 3-11), received zevor-cel infusion. A single infusion of zevor-cel was administered 1-2 days after the completion of lymphodepletion. Three participants received 1.0×108 CAR+ T cells, and 11 participants received 1.5×108 CAR+ T cells. The median age of the cohort was 54 years (range: 34-62 years); 50.0% (7/14) of the participants had high-risk cytogenetic abnormalities, 14.3% (2/14) had extramedullary disease (EMD), and 14.3% (2/14) of the participants had Stage III disease based on International Staging System (ISS).

Safety
Overall, the safety profile of zevor-cel was manageable. There were no ≥ Grade 3 cytokine release syndrome (CRS) events. There were no immune effector cell-associated neurotoxicity syndrome (ICANS) events of any grade. Three treatment-related Grade 3 infections were observed. Three patients experienced serious adverse events (SAE) including 2 patients who had treatment-related SAEs which were pulmonary infection and tumor lysis syndrome. There were overall 2 deaths on the study; neither was related to zevor-cel.

Efficacy
As of July 17, 2023, the median follow-up duration was 37.7 months (range:14.8-44.2 months). The overall response rate (ORR) was 100% (14/14) with 78.6% (11/14) patients achieving a complete response (CR) or a stringent complete response (sCR); minimal residual disease (MRD) negativity was attained in all patients achieving either a CR or sCR. The median duration of response (mDOR) was 24.1 months in all patients and 26.0 months in those achieving CR or sCR. The median progression-free survival (mPFS) was 25.0 months. A total of 7 (50%) patients were in remission lasting longer than 24 months. The median overall survival (OS) was not reached, and 92.9% (13/14) of patients were still alive at month 36.

Conclusion
At 3-year follow up of Phase I portion of LUMMICAR-1 study in heavily pre-treated R/R MM population, zevor-cel demonstrated an encouraging safety profile with deep and durable responses consistent with the initial results.

About Zevor-cel
Zevor-cel (CT053) is a fully human, autologous BCMA CAR T-cell product candidate for the treatment of R/R MM. The New Drug Application (NDA) for zevor-cel is based on the Phase I/II data from LUMMICAR STUDY 1 in China and is currently under review. CARsgen is conducting a Phase 1b/2 LUMMICAR STUDY 2 clinical trial in North America to evaluate the safety and efficacy of zevor-cel for R/R MM.

Zevor-cel received Regenerative Medicine Advanced Therapy (RMAT) and Orphan Drug designations from the U.S. FDA in 2019, as well as Priority Medicines (PRIME) and Orphan Medicinal Product designations from the European Medicines Agency (EMA) in 2019 and 2020, respectively. Zevor-cel also received Breakthrough Therapy designation from the NMPA in 2020.

About CARsgen Therapeutics Holdings Limited
CARsgen is a biopharmaceutical company with operations in China and the U.S. and is focused on innovative CAR T-cell therapies for the treatment of hematologic malignancies and solid tumors. CARsgen has established a comprehensive CAR T-cell research and development platform, encompassing target discovery, innovative CAR T-cell development, clinical trials, and commercial-scale production. CARsgen has internally developed novel technologies and a product pipeline with global rights to address major challenges of CAR T-cell therapies, such as improving the safety profile, enhancing the efficacy in treating solid tumors, and reducing treatment costs. CARsgen’s vision is to become a global biopharmaceutical leader that brings innovative and differentiated cell therapies to cancer patients worldwide and makes cancer curable.

Forward-looking Statements
All statements in this press release that are not historical fact or that do not relate to present facts or current conditions are forward-looking statements. Such forward-looking statements express the Group’s current views, projections, beliefs and expectations with respect to future events as of the date of this press release. Such forward-looking statements are based on a number of assumptions and factors beyond the Group’s control. As a result, they are subject to significant risks and uncertainties, and actual events or results may differ materially from these forward-looking statements and the forward-looking events discussed in this press release might not occur. Such risks and uncertainties include, but are not limited to, those detailed under the heading "Principal Risks and Uncertainties" in our most recent annual report and interim report and other announcements and reports made available on our corporate website, https://www.carsgen.com. No representation or warranty is given as to the achievement or reasonableness of, and no reliance should be placed on, any projections, targets, estimates or forecasts contained in this press release.

Contact CARsgen
For more information, please visit https://www.carsgen.com/
Public Relations: [email protected]
Investor Relations: [email protected] 

Source : CARsgen Presents Updated Research Results on Zevor-cel at 2023 ASH Annual Meeting

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Twelfth annual Crossed Swords will see Stamus Networks share expertise and technology to develop and test the capabilities and practical skills of participants

TALLINN, Estonia, Dec. 12, 2023 /PRNewswire/ — Stamus Networks, a global provider of high-performance network-based threat detection and response systems, today announced it is once again participating in Crossed Swords, organized by the NATO Cooperative Cyber Defence Center of Excellence (CCDCOE) in Tallinn, Estonia. The exercise runs from December 12-14.

Since it was first developed in 2014, Crossed Swords focuses on full-spectrum offensive cyber operations, exploring every possible attack vector and technique potentially used by adversaries. The event, which is designed to help make NATO members build a more resilient defense against cyber adversaries, brings together hundreds of participants from around the world. They’ll be training in the areas of cyber red teaming, penetration testing, digital forensics, situational awareness, and monitoring techniques. The exercise uses realistic technologies and attack methods, with the goal of building a resilient defense through knowing the most current attack methods and tools. This year, participants from 21 countries are taking part, including a team of Stamus Networks engineers.

"By partnering with the CCDCOE and our NATO allies in these exercises, we’re putting our technologies and skills to the test in real-world scenarios," said Ken Gramley, CEO of Stamus Networks. "There’s no better proving ground to demonstrate that our solutions work, uncover ways that they can become even stronger, and to support cyber defenders around the globe."

Since 2016, Stamus Networks has worked with the CCDCOE in numerous live fire exercises, including Locked Shields, the largest live-fire cyber defense exercise in the world, providing both personnel and its network security solutions. This includes educational workshops and its network detection and response (NDR) system – the Stamus Security Platform.

To learn more about the NATO Cooperative Cyber Defence Centre of Excellence (CCDCOE) and the exercise Crossed Swords, visit the website: https://ccdcoe.org/exercises/crossed-swords/.

About Stamus Networks: 

Stamus Networks believes in a world where defenders are heroes, and a future where those they protect remain safe. As organizations face threats from well-funded adversaries, we relentlessly pursue solutions that make the defender’s job easier and more impactful. The global leader in Suricata-based network security solutions, Stamus Networks helps enterprise security teams know more, respond sooner and mitigate their risk with insights gathered from cloud and on-premise network activity. Our Stamus Security Platform combines the best of intrusion detection (IDS), network security monitoring (NSM), and network detection and response (NDR) systems into a single solution that exposes serious and imminent threats to critical assets and empowers rapid response. For more information visit: stamus-networks.com.

Source : Stamus Networks Supports NATO Red Teaming Cyber Exercise for the Fifth Consecutive Year

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NEW YORK, Dec. 12, 2023 /PRNewswire/ — The Metal Payment Card competitive assessment by global technology intelligence firm ABI Research provides an in-depth, unbiased examination and ranking of ten prominent providers of Metal Payment Cards. The rankings are based on various chosen criteria, split into two overarching categories, covering implementation and innovation, including durability, design features/capabilities, security, sustainability, convergent technologies, global reach, product/service range, market share for overall and metal payment cards, and partnerships/customers. These criteria were identified as vital for the metal payment card market’s continual market development and relevance. The companies evaluated and ranked are:

Market Leaders: CompoSecure, IDEMIA, and Thales
Mainstream: Giesecke+Devrient and BIOSMART
Followers: CPI Card Group, Kona I, Toppan, Thames Technology, and ICK

"Financial institutions are constantly competing to differentiate themselves from their competitors, which has placed the metal payment card as an offering in a prime position to provide a demonstrable physical and tangible value. The metal payment card has successfully carved out its own segment in the payment cards market by offering a secure and durable option for banks and their end-users, alongside the physical appeal," explains Sam Gazeley, Digital Payment Technologies Analyst at ABI Research.

ABI Research ranked CompoSecure as the market leader in the assessment because it goes beyond metal. It combines Gorilla Glass’s Lux Glass offering and Echo Mirror’s mirror solution to supply banks with one-of-a-kind differentiated payment cards. This is supported by the fact that other vendors use their offerings to supply projects, ensuring a consistently strong level of business for CompoSecure.  

IDEMIA ranked second on the overall scores and first in implementation through its strong presence in a wide range of countries, historically strong position in the payment card market, and its acquisition of X Core, reinforcing its range of innovative personalization options for metal payment cards.

Thales rounded out the market leaders, earning third place overall, ranking second in innovation, and third in implementation due to its strong portfolio of metal payment cards, alongside a well-established history of supplying EMV payment card projects in all regions. Thales has also made great strides in stainless steel and tungsten recycling, localized metal card production to reduce transport-linked carbon output, and recycling programs for issuer-led collection and recycling.

"It is evident that, as the metal payment card has become more commonly included in financial institutions’ payment card portfolios, vendors active in this space have had to rapidly develop compelling and attractive solutions to secure a place in this growing market segment, with the best innovators and implementers securing a wider share of the market," Gazeley concludes.

These findings are from ABI Research’s Metal Payment Card competitive ranking report. This report is part of the company’s Digital Payment Technologies and Cybersecurity Applications research services, which include research, data, and ABI Insights. Competitive Ranking reports offer a comprehensive analysis of implementation strategies and innovation and market share analysis to offer unparalleled insight into a company’s performance and standing compared to its competitors.

About ABI Research

ABI Research is a global technology intelligence firm delivering actionable research and strategic guidance to technology leaders, innovators, and decision makers around the world. Our research focuses on the transformative technologies that are dramatically reshaping industries, economies, and workforces today.

ABI Research是一家国际科技情报公司，为全球科技领袖、创新人士和决策者提供实用的市场研究和战略性指导。我们密切关注一切为各行各业、全球经济和劳动市场带来颠覆性变革的创新与技术。

For more information about ABI Research’s services, contact us at +1.516.624.2500 in the Americas, +44.203.326.0140 in Europe, +65.6592.0290 in Asia-Pacific, or visit www.abiresearch.com.

Contact Info:
Global 
Deborah Petrara 
Tel: +1.516.624.2558 
[email protected] 

Source : CompoSecure, IDEMIA, and Thales Named Market Leaders in ABI Research's Metal Payment Card Competitive Ranking

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TORONTO, Dec. 12, 2023 /PRNewswire/ — Visionary Education Technology Holdings Group Inc. (the "Company") (NASDAQ: GV), a private education provider with technology of artificial intelligence and life science on the cutting edge, today announced the Vice President of Algoma University, along with a team of executives, visited the Company. They conducted a thorough tour of the two buildings located at 105 and 95 Moatfield Drive.

The Company successfully acquired the two buildings on September 23, 2022. The two office buildings with a total of approximately 433,000 square feet of space at 95-105 Moatfield Drive, Toronto, which used to be the Canadian headquarters of IBM and Kraft Heinz.

The purpose of the university team’s visit is to explore collaboration opportunities with the Company in educational projects.

Algoma University, is a public university with its main campus located in Sault Ste. Marie, Ontario, Canada. Algoma U is a teaching-focused and student-centred post-secondary institution, specializing in liberal arts, sciences, management and professional degree programs. Algoma University has three campuses in Ontario, each with its own unique features. The two campuses that primarily welcome international students are the Sault Ste. Marie campus and the Brampton campus.

The team from Algoma University was deeply impressed by the facilities and business scale of the Company. Both parties expressed a willingness to collaborate on multiple projects.

Ms. Zhou, Chief Executive Officer and Chairman of the Board of the Company commented: "We aim to develop the 95-105 buildings into a leading comprehensive university facility in Toronto. As part of our strategic initiatives, we plan to lease portions of the facility to third party university educational organizations with whom we may join in providing educational services. Algoma University’s open, innovative, and inclusive spirit aligns well with the Company. We look forward to collaborating with Algoma University to make a greater contribution to the development of Canada’s diverse ethnicities and cultures."

About Visionary Education Technology Holdings Group Inc.

Visionary Education Technology Holdings Group Inc., headquartered in Toronto, Canada, is a private education provider located in Canada, with subsidiaries in Canada and market partners in China, that offers high-quality education resources to students around the globe. The Company aims to provide access to secondary, college, undergraduate and graduate and vocational education to students in Canada through technological innovation so that more people can learn, grow and succeed to their full potential. As a fully integrated provider of educational programs and services in Canada, the Company has been serving and will continue to serve both Canadian and international students. For more information, visit the Company’s website at https://ir.visiongroupca.com/.

Forward-Looking Statements

All statements other than statements of historical fact in this announcement are forward-looking statements. These forward-looking statements involve known and unknown risks and uncertainties and are based on the Company’s current expectations and projections about future events that the Company believes may affect its financial condition, results of operations, business strategy and financial needs. Investors can identify these forward-looking statements by words or phrases such as "believes," "expects," "anticipates," "estimates," "intends," "would," "continue," "should," "may," or similar expressions. The Company undertakes no obligation to update or revise publicly any forward-looking statements to reflect subsequent occurring events or circumstances, or changes in its expectations, except as may be required by law. Although the Company believes that the expectations expressed in these forward-looking statements are reasonable, it cannot assure you that such expectations will turn out to be correct, and the Company cautions investors that actual results may differ materially from the anticipated results and encourages investors to review other factors that may affect its future results in the Company’s registration statement and in its other filings with the SEC.

For more information, please contact:
Visionary Education Technology Holdings Group Inc.
Investor Relations Department
Email: [email protected]

Source : Algoma University Executives Visited GV Headquarter in Toronto

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Collaborative partnership simplifies how customers procure, deploy and utilize leading solutions to enhance cyber resiliency

ATLANTA, Dec. 12 2023 /PRNewswire/ — Secureworks (NASDAQ: SCWX), a global leader in cybersecurity, today announced a joint go-to-market program with SentinelOne (NYSE:S), a global leader in AI-powered security, designed to accelerate organizational cyber resilience. The new channel program brings together Secureworks® Taegis™ ManagedXDR and SentinelOne Singularity™ Complete, two fully integrated, industry-leading cybersecurity solutions to simplify risk management and reduce time to value by utilizing cyber expertise, threat intelligence and technology.

Today’s announcement builds on the companies’ technological integration announced earlier in 2023 and underscores their investment in enabling organizations to deliver the right cybersecurity outcomes for their business. The fully integrated Secureworks Taegis XDR and SentinelOne Singularity Complete solution gives customers access to two world-class threat intelligence teams and 24/7 managed threat detection and response that employs telemetry from across their cyber estate. With this insight, businesses can detect a wider range of threats more rapidly and maximize security investments. The Secureworks and SentinelOne program is available globally via the cybersecurity partner community.

"Organizations know that they can’t afford to elevate their cybersecurity posture after a breach. They want to understand their risk and break down silos because overcomplexity is enabling threat actors to lurk unseen. Our partnership with SentinelOne will shine a bright light into the dark recesses of cyber environments, empowering organizations to build a more resilient and sustainable cybersecurity infrastructure," said Chris Bell, VP Strategy and Corporate Development, Secureworks. "Our deep end-to-end go-to-market with SentinelOne is rarer than it should be in our industry. We are both committed to working together because we recognize working as a united community is the only way to change the economics of cybercrime."

Complex platforms that create friction and silos within the security environment, are thwarting organizations’ attempts to build agile cyber environments and maximize return on investment. One of the key objectives of the new Secureworks and SentinelOne partnership is to make advanced, market-leading cybersecurity solutions more accessible, integrated and affordable to a broader range of enterprises. The joint program offers solution providers enhanced training, the Secureworks and SentinelOne bi-directional technology integration, as well as access to hundreds of API integrations at no additional cost and joint marketing activity at a partner level.

"Customers are telling us that they need high value cybersecurity. They don’t want poorly pieced together technologies masquerading as ‘partnerships’ because they create silos and complexity that they simply don’t have the expertise or resources to manage," commented Mark Mahovlich, Vice President of Strategy and Execution, ICM Cyber. "That’s what is so impressive about the Secureworks and SentinelOne approach, the technology is integrated end-to-end, making it usable, accessible and highly functional. It’s a breath of fresh air for us because it is a package truly tailored to the partner community that will drive mutual growth."

"At SentinelOne, our mission is to arm organizations with the tools they need to respond to cyber threats swiftly and effectively. Teaming up with Secureworks is more than a partnership; it’s a commitment to delivering on that mission," said Ken Marks, VP Worldwide Channel, SentinelOne. "Together with Secureworks we can provide every company, regardless of size or budget, with access to world-leading AI-based cybersecurity technology that enables them to secure the entire enterprise in a simple, unified way."

About Secureworks 

Secureworks (NASDAQ: SCWX) is a global cybersecurity leader that secures human progress with Secureworks® Taegis™, a SaaS-based, open XDR platform built on 20+ years of real-world detection data, security operations expertise, and threat intelligence and research. Taegis is embedded in the security operations of over 4,000 organizations around the world who use its advanced, AI-driven capabilities to detect advanced threats, streamline and collaborate on investigations, and automate the right actions.

Connect with Secureworks via X, LinkedIn and Facebook and Read the Secureworks Blog.

About SentinelOne

SentinelOne is a global leader in AI-powered security. SentinelOne’s Singularity™ Platform detects, prevents, and responds to cyber attacks at machine speed, empowering organizations to secure endpoints, cloud workloads, containers, identities, and mobile and network-connected devices with speed, accuracy and simplicity. Over 11,500 customers, including Fortune 10, Fortune 500, and Global 2000 companies, as well as prominent governments, trust SentinelOne to secure the future today. To learn more, visit www.sentinelone.com

Source : Secureworks and SentinelOne® Deliver Trailblazing Global Joint Go-To-Market Program to Decrease Cyber Risk

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Innovative cloud solution enables Payment Card Industry (PCI) compliance with evolving standards for merchants of any size

PLANO, Texas, Dec. 12, 2023 /PRNewswire/ — Ribbon Communications Inc. (Nasdaq: RBBN), a global provider of real time communications technology and IP optical networking solutions to many of the world’s largest service providers, enterprises, and critical infrastructure operators to modernize and protect their networks, today announced that global solutions provider BroadSource has selected Ribbon’s SBC SWe as a key component in its Payment Card Industry Data Security Standard (PCI-DSS) compliant secure payments system, SecureCall.

"Ribbon’s global leadership and extensive SBC installed base gave us the necessary confidence to include them as a critical part of our solution," said Haydn Faltyn, CEO and Co-founder, BroadSource."We look forward to working together as customers around the world upgrade their systems to become PCI-DSS 4.0 compliant from March 2024, allowing them to secure their customers’ card payments made over the phone in both call center and non-call center environments".

PCI-DSS is a global payments industry standard for keeping consumer credit card data secure when payment information is transmitted online or over the phone. While large contact centers may have solutions in place, multiple locations remain where credit card information is shared over the phone, verbally. The latest PCI standards tighten a business’s obligations and require that these informal settings be better secured. When SecureCall removes the customer’s card details from the conversation, the business no longer has visibility into the customer’s card details.

SecureCall leverages Ribbon’s award-winning SBC technology to participate in a secure conversation between the merchant, customer and SecureCall Cloud. The solution is acquired as a cloud service and deployed by the merchant’s telecom service provider, freeing the merchant from new technology investments. Security features including DTMF (Dual Tone Multi Frequency) Clamping can be enabled on any cloud phone line, so the service is available no matter where the merchant’s staff is located — a physical store, a call center environment or a remote workstation. Retail employees and agents can securely take credit card information over the phone without pausing calls or screen recordings.

"We’re proud of our ability to help our customers ensure the security of business-critical communications and meet industry and government-led security mandates around the world," said Manny Christophidis, Enterprise and Channel Director, Asia Pacific, Ribbon Communications. "We look forward to supporting BroadSource’s innovation and dedication to customer success well into the future."

About Ribbon
Ribbon Communications (Nasdaq: RBBN) delivers communications software, IP and optical networking solutions to service providers, enterprises and critical infrastructure sectors globally. We engage deeply with our customers, helping them modernize their networks for improved competitive positioning and business outcomes in today’s smart, always-on and data-hungry world. Our innovative, end-to-end solutions portfolio delivers unparalleled scale, performance, and agility, including core to edge software-centric solutions, cloud-native offers, leading-edge security and analytics tools, along with IP and optical networking solutions for 5G. We maintain a keen focus on our commitments to Environmental, Social and Governance (ESG) matters, offering an annual Sustainability Report to our stakeholders. To learn more about Ribbon, please visit rbbn.com.

About BroadSource
We are a global systems integration and software development company that builds and operates platforms for CSPs worldwide. Our flagship product, EMU, supports a wide range of pre-built automations and integrations for Collaboration Clouds. Our latest innovation, SecureCall, presents CSPs with an untapped opportunity to differentiate their Cloud offering. SecureCall makes PCI-DSS compliance for payments by phone possible for any sized business and has become the ‘go-to’ architecture for mediation and orchestration of complex Cloud Collaboration services.
BroadSource is headquartered in Melbourne, with offices in London, Seattle, Düsseldorf, Delhi and delivers products and services to customers in Europe, North and South America, Africa and Asia.

Important Information Regarding Forward-Looking Statements
The information in this release contains forward-looking statements regarding future events that involve risks and uncertainties. All statements other than statements of historical facts contained in this release, including those regarding the expected benefits from use of Ribbon Communication’s products, are forward-looking statements. The actual results of Ribbon Communications may differ materially from those contemplated by the forward-looking statements. For further information regarding risks and uncertainties associated with Ribbon Communications’ business, please refer to the "Risk Factors" section of Ribbon Communications’ most recent annual or quarterly report filed with the SEC. Any forward-looking statements represent Ribbon Communications’ views only as of the date on which such statement is made and should not be relied upon as representing Ribbon Communications’ views as of any subsequent date. While Ribbon Communications may elect to update forward-looking statements at some point, Ribbon Communications specifically disclaims any obligation to do so.

Investor Contact 
+1 (978) 614-8050
[email protected]

Media Contact
Catherine Berthier
+1 (646) 741-1974
[email protected] 

ANZ Media Contact:
Terry Alberstein
Navigate Communication
[email protected]
+61(0) 458 484 921

BroadSource Media Contact:
Jacqueline Thals
+61 418 668 068
[email protected]

Source : BroadSource Partners with Ribbon to Enhance Credit Card Data Security

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