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Everest Medicines Announces Investigational New Drug Application Acceptance of Zetomipzomib in China

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— Everest plans to contribute to the ongoing global Phase 2b PALIZADE trial of zetomipzomib in active lupus nephritis – 

— Zetomipzomib demonstrated clinically meaningful renal responses with a favorable tolerability profile in an earlier Phase 2 trial —

— Renal and autoimmune diseases are key focus areas for Everest and zetomipzomib is expected to solidify the Company’s Asia leadership position in this space –

SHANGHAI, Dec. 4, 2023 /PRNewswire/ — Everest Medicines (HKEX 1952.HK, "Everest", or the "Company"), a biopharmaceutical company focused on the development, manufacturing and commercialization of innovative medicines and vaccines, today announced that China National Medical Products Administration (NMPA) has accepted its investigational new drug (IND) application for zetomipzomib in China. Zetomipzomib is a novel, first-in-class, selective immunoproteasome inhibitor currently being evaluated for a range of immune-mediated disorders, including lupus nephritis (LN). 

Everest plans to join its partner, Kezar Life Sciences, in PALIZADE, a global, placebo-controlled Phase 2b clinical trial evaluating the efficacy and safety of two dose-levels of zetomipzomib in patients with active LN. LN is the most common secondary immune-mediated glomerular disease, which may gradually lead to kidney failure. There are an estimated 400,000-600,000 LN patients in China.

"The IND acceptance of zetomipzomib marks an important step towards entering clinical studies in China. We look forward to participating in the PALIZADE trial to enroll LN patients in the nation which has a high prevalence of the disease," said Rogers Yongqing Luo, Chief Executive Officer of Everest Medicines. "Renal and autoimmune diseases are key therapeutic areas for Everest, and zetomipzomib represents another mid-to-late-stage pipeline asset that will solidify our leading position in these therapeutic areas in Asia."

Zetomipzomib demonstrated positive results from an earlier Phase 2 trial, with clinically meaningful overall renal response rate of 64.7% at Week 25 (end of treatment) and 88.2% at Week 37. Complete renal response rate was 35.3% at Week 25 and 41.2% at Week 37. Mean reduction in urine protein creatinine ratio (UPCR) from baseline was 57.0% at week 25 and 83.0% at week 37, while estimated glomerular filtration rate (eGFR) remained stable during treatment. Zetomipzomib also showed a favorable safety and tolerability profile during the trial with no new safety signals during the follow-up period.

About Zetomipzomib

Zetomipzomib (KZR-616) is a novel, first-in-class, selective immunoproteasome inhibitor with broad therapeutic potential across multiple autoimmune diseases. Preclinical research demonstrates that selective immunoproteasome inhibition results in a broad anti-inflammatory response in animal models of several autoimmune diseases, while avoiding immunosuppression. Data generated from Phase 1 and Phase 2 clinical trials provide evidence that zetomipzomib exhibits a favorable safety and tolerability profile for development in severe, chronic autoimmune diseases.

About the PALIZADE Trial

PALIZADE is a global, placebo-controlled, randomized, double-blind Phase 2b clinical trial evaluating the efficacy and safety of two dose-levels of zetomipzomib in patients with active LN. Target enrollment will be 279 patients, randomly assigned to receive 30 mg of zetomipzomib, 60 mg of zetomipzomib or placebo subcutaneously once weekly for 52 weeks, in addition to standard background therapy. Background therapy can, but will not be mandated to, include standard induction therapy. Over the initial 16 weeks, there will be a mandatory corticosteroid taper to 5 mg per day or less. End-of-treatment assessments will occur at Week 53. The primary efficacy endpoint is the proportion of patients who achieve a complete renal response (CRR) at Week 37, including a urine protein-to-creatine ratio (UPCR) of 0.5 or less without receiving rescue or prohibited medications.

About Everest Medicines

Everest Medicines is a biopharmaceutical company focused on developing, manufacturing and commercializing transformative pharmaceutical products and vaccines that address critical unmet medical needs for patients in Asian markets. The management team of Everest Medicines has deep expertise and an extensive track record from both leading global pharmaceutical companies and local Chinese pharmaceutical companies in high-quality discovery, clinical development, regulatory affairs, CMC, business development and operations. Everest Medicines has built a portfolio of potentially global first-in-class or best-in-class molecules in the company’s core therapeutic areas of renal diseases, infectious diseases and autoimmune disorders. For more information, please visit its website at www.everestmedicines.com.

Forward-Looking Statements:

This news release may make statements that constitute forward-looking statements, including descriptions regarding the intent, belief or current expectations of the Company or its officers with respect to the business operations and financial condition of the Company, which can be identified by terminology such as "will," "expects," "anticipates," "future," "intends," "plans," "believes," "estimates," "confident" and similar statements. Such forward-looking statements are not guarantees of future performance and involve risks and uncertainties, or other factors, some of which are beyond the control of the Company and are unforeseeable. Therefore, the actual results may differ from those in the forward-looking statements as a result of various factors and assumptions, such as future changes and developments in our business, competitive environment, political, economic, legal and social conditions. The Company or any of its affiliates, directors, officers, advisors or representatives has no obligation and does not undertake to revise forward-looking statements to reflect new information, future events or circumstances after the date of this news release, except as required by law.

Source : Everest Medicines Announces Investigational New Drug Application Acceptance of Zetomipzomib in China

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This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network

Xylonix Study Reveals Link Between COVID-19 and Non-COVID-19 Excess Deaths

Xylonix Study Reveals Link Between COVID-19 and Non-COVID-19 Excess Deaths

SINGAPORE – Media OutReach – 4 December 2023 – A new study shows that COVID-19 infection might be causing high numbers of unexpected deaths previously believed to be unrelated to COVID-19. These findings, reported by immuno-oncology biotech company Xylonix, offer new directions for potential strategies to address the enduring impacts of COVID-19 on public health.

Long Covid and Non-Covid-19 Excess Deaths
Non-COVID-19 excess deaths are an increase in deaths unrelated to COVID-19 infection beyond the recent years’ averages. This trend of additional deaths is mainly led by deaths in the age groups between 15 and 45 at levels above 20% in the first half of 2023. While the cause is previously unidentified, the research led by Dr. Jinhyuk Fred Chung, Chief Scientific Officer of Xylonix, uncovered that up to 76% of the Non-COVID-19 excess deaths could be explained by Long COVID-patterns.

Long COVID refers to a state whereby individuals experience persistent symptoms of COVID-19 from immunity malfunctions following their initial recovery from the infection. The study’s findings suggest that such sustained immunity malfunctions can result in damage to blood vessels and tissues, which increases patients’ susceptibility to long-term health complications and resultant deaths.

“With this newfound understanding of the underlying pathological mechanisms, we can explore new research directions to identify potential interventions for the prevention of excess deaths in patients,” said Dr. Chung.

Interventions for Prevention and Treatment
Several avenues are proposed, such as avoiding strenuous exercise after a recent infection recovery and adopting prevention habits that complement vigilant standard hygienic practices. These include using antiviral hygiene nasal sprays, which deactivate the SARS-CoV-2 virus in the nasal passages to offer an extra layer of protection.

Other measures involve treatments targeting specific overactive immune cells to recalibrate the immune system. The study also highlighted the use of blood-lipid lowering or non-steroidal, non-anticoagulant therapies to mitigate complications that drive long COVID.

Taking the lead in implementing these recommendations to support public health, Xylonix is donating up to 2,500 bottles of nasal spray each month to elderly homes and healthcare facilities in Singapore. The initiative offers vulnerable individuals a solution to bolster their resilience in the ongoing battle against the evolving challenges from airborne pathogens. Members of the public can also purchase these sprays on Amazon and Shopee.
Hashtag: #covid19 #Xylonix


The issuer is solely responsible for the content of this announcement.

About Xylonix

Xylonix (Xylonix Pte. Ltd.) is an immuno-oncology biotech that is developing a new way of combating cancer through PARP1 DNA-repair overdrive for toxicity-free, widely applicable and curative first-in-class cancer immunotherapy drugs. Dubbed as onco-parthanatos agents, Xylonix’s lead development candidate 010DS-Zn is being developed for arresting cancer spread and relapse post-surgery, radiation, or systemic treatments.

For more information, visit .

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This content was prepared by Media OutReach. The opinions expressed in this article are the author's own and do not reflect the view of Siam News Network.

TradeFlow Capital Management collaborates with Abu Dhabi-based metals digital trader Open Mineral to launch 'Critical Minerals Trade Finance Fund' and Trading Platform

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Open Mineral

New Fund and Trading Platform will help address the global energy transition urgency. Critical minerals are vital for the energy transition and the UAE stands to be a market leader in the emerging new energy economy.

SINGAPORE, Dec. 4, 2023 /PRNewswire/ — Singapore-based Fintech-powered Fund management firm TradeFlow Capital Management (TradeFlow) and Abu Dhabi based digital trader Open Mineral have joined forces, launching the ‘Critical Minerals Trade Finance Fund’ and a new TradeFlow Metals platform to help address urgent global energy transition needs. Open Mineral will be a Founding Client, providing a multi-year commitment to this collaboration that will connect new and existing trade finance investors and banks with digitally de-risked transactions of global critical minerals flows including copper, lithium and zinc.

The "Critical Minerals Trade Flow Fund" and TradeFlow Metals digital platform were launched at the recent Abu Dhabi Finance Week 2023.

Dr. Tom James, CEO and co-founder of TradeFlow, highlights: "Open Mineral brings a remarkable team of metals trading experts who possess a strong digital DNA aligned with ours. We are excited to see the establishment of two new entities today, aimed at fostering the growth of the commodities trading industry in the UAE. The first entity is the ‘Critical Minerals Trade Flow Fund’, managed by TradeFlow.

The second entity is the ‘TradeFlow Metals platform’, which will operate as an independent and fully separated entity. This platform will leverage the skills and expertise of TradeFlow’s technology provider and long-term partner, Liberatech Plus, which has already assisted in the processing of over 3,000 trades and USD3 billion in cross-commodity cargoes since 2018.

This is a great opportunity to participate with our partners to bring the advantages of FinTech and liquidity to the transition metals market with our digitalised solutions. This is a great success for all involved and the transition metals and energy markets as a whole."

James Rilett, Chief Product Officer of Open Mineral affirms: "We are honoured and proud to be the Founding Client of  the Critical Minerals Trade Flow Fund. In partnership with TradeFlow, we are committed to bringing proven Risk Transformation methodology and technology to the critical minerals sector. Open Mineral has one of the fastest growing critical minerals books in the world and we see no shortage of opportunity to trade more of these flows, but our industry needs capital. Since incorporating in Abu Dhabi Global Market in 2022, we have profitably traded over $500mn of metals."

Mr. Rilett further explains: "This is a crucial phase in the transition of the regional economies, and we want to de-risk and capture opportunities at scale. Commodities as an asset class has a high risk, high complexity reputation, with tech and data changing this risk profile. Our strategic role in enabling global trade finance to meet these new opportunities serves to enhance and catalyse the regional economies. To be combining this game-changing trade finance platform with Open Mineral’s trade book and metals know-how was an unmissable opportunity."

According to the International Energy Agency (IEA), the market for energy transition metals was USD320bn in 2022, which based on Open Mineral assessment will treble in the next 10 years. This  collaboration with TradeFlow shall be an effective means of addressing critical metals demand.

About TradeFlow Capital Management (Tradeflow)

TradeFlow is the world’s first Fintech-powered commodity trade enabler focused on SMEs. TradeFlow consists of a diverse team of experts with the focused mission of addressing the increasing trade finance gap faced by global SMEs operating as producers/traders/end-users in the bulk commodity trading space. By performing an enabling role in international trade and globalization, TradeFlow creates growth opportunities for businesses and economies.

To date, TradeFlow has successfully invested in more than US$3 Bn of physical commodity trade through 3000+ transactions across 18+ countries and 30+ commodity types, with more than 1800 SME counterpart entities KYC reviewed. As part of its unique business model, The TradeFlow Funds*, advised by TradeFlow, were conceived in 2016 and launched in 2018.

TradeFlow is a Partner of the International Chamber of Commerce (ICC) to mobilise capital and improve trade finance access for SMEs worldwide through the "’ICC Trade Now" and "ICC Digital Trade Standards Initiative" platforms.

For more information, please visit: www.tradeflow.capital   

About Liberatech Plus

Liberatech Plus is a leading provider of cutting-edge and scalable solutions that empower businesses in the commodities supply and trading industries. Our innovative technologies are designed to remove barriers, enhance transparency, and drive innovation in global trade. From small and medium enterprises (SMEs) to multinational corporations (MNCs), our solutions enable clients to thrive in the dynamic commodities markets and benefit from the digitalisation of global supply chains. We offer a comprehensive range of advanced solutions, including state-of-the-art Commodity Trading and Risk Management (CTRM) systems, and all-encompassing Digital Trade Services (DTS).

With our expertise and forward-thinking solutions, we actively contribute to economic growth and foster a world where geographical borders, financial constraints, and technological barriers no longer hinder global trade.


Open Mineral

About Open Mineral

After securing funding from Mubadala Investment Co, amongst others, Open Mineral accelerated its growth plan last year by opening offices in Abu Dhabi and Shanghai, where the company expects to double its headcount over the coming year. Currently headquartered in Zug, Switzerland, Open Mineral has a global presence with offices in Latin America, UAE, China, the Americas, Asia, and Europe. Open Mineral is a physical commodity trader powered by technology and market intelligence, enabling profitable and efficient trading of raw material commodities. Founded in 2016 by a team of ex-Glencore traders based in Baar, Switzerland – The Open Mineral platform has onboarded over 900 metals and mining companies from 40 countries.

For more information, please visit: www.openmineral.com 

Source : TradeFlow Capital Management collaborates with Abu Dhabi-based metals digital trader Open Mineral to launch 'Critical Minerals Trade Finance Fund' and Trading Platform

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This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network

Samyang Corporation's Eco-Friendly Transparent Flame-Retardant Polycarbonate, Proven Free of Per- and Polyfluoroalkyl Substances

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SGS, a global inspection and testing company conducts tests for 74 types of per and polyfluoroalkyl substances Per- and polyfluoroalkyl substances, difficult to biodegrade and accumulate in the body, cause diseases. Regulatory strengthening trend worldwide Eco-friendly material not using flame retardants. Achieves highest flame-retardant rating, superior chemical resistance and low temperature impact strength compared to standard PC

SEOUL, South Korea, Dec. 4, 2023 /PRNewswire/ — Samyang Corporation targets the global market with its eco-friendly and safety proven transparent flame-retardant polycarbonate material.

Samyang Corporation (CEO Kang Ho-seong) announced on the 4th that its self-developed eco-friendly transparent flame-retardant polycarbonate was tested and found to be free of harmful per- and polyfluoroalkyl substances (PFAS).

Per- and polyfluoroalkyl substances, artificial substances composed of carbon and fluorine, are widely used in electrical and electronic products, food packaging, cosmetics, textiles, and firefighting equipment due to their thermal stability and resistance to water and oil. Termed as "forever chemicals" due to their resistance to natural decomposition, they accumulate in the environment and human body, causing environmental pollution and health issues such as tumors, thyroid disruption, and hormonal imbalances.

Due to these hazards, the United States has already started regulating per- and polyfluoroalkyl substances, and the European Union is pushing for legislation to ban their use, including in harmful chemicals, with other countries also moving toward regulations restricting their use.

Samyang Corporation conducted tests for 74 types of per- and polyfluoroalkyl substances in this test. Key substances tested include Perfluorooctanesulfonic acid (PFOS), which can cause chronic renal failure, and Perfluorooctanoic acid (PFOA), known to increase the rate of birth defects and cause various severe diseases such as cancers and thyroid disorders.  In addition, tests were conducted for Perfluorohexanesulfonic acid (PFHxS), Perfluoroalkyl carboxylic acids (PFCA), and various per- and polyfluoroalkyl substances, and the results showed no detection of these harmful substances.

SGS, a global inspection and testing company, conducted the detection test for per- and polyfluoroalkyl substances. Established in 1878, SGS operates 2,600 offices and laboratories worldwide, and is highly regarded for its inspection and verification reliability and compliance with international standards. 

Samyang Corporation’s transparent flame-retardant polycarbonate is an eco-friendly material developed by changing the molecular bonding structure based on silicone polycarbonate (Si-PC), without adding halogen-based flame retardants like chlorine and bromine, which produce toxic gases when incinerated.

It overcomes the drawbacks of traditional flame-retardant polycarbonates with decreased transparency and impact strength, and its chemical resistance and low temperature impact strength are superior to regular polycarbonate. The flame-retardant quality is also exceptional, having obtained the highest rating of "V-0" in the UL 94 vertical burn test developed by "UL (Underwriters Laboratories)," a U.S. safety standards development and certification organization. V-0 is awarded only to plastics that self-extinguish within 10 seconds when ignited vertically.

Samyang Corporation plans to expand the use of this material in various industries requiring transparency and flame-retardancy, such as automotive and home appliance exteriors and interiors, sound barriers, and medical device parts, based on its capability to maintain mechanical properties at a similar level to regular polycarbonate even when processed into thin films of about 1 mm thick.

Samyang Corporation’s CEO Kang Ho-seong stated, "The recent environmental pollution and human health issues caused by per- and polyfluoroalkyl substances have become a global concern, leading countries to strengthen regulations on their use. Based on the results of per- and polyfluoroalkyl substance tests, we plan to accelerate the global expansion of transparent flame-retardant polycarbonate, while also leading in the development of eco-friendly and high-functionality materials."

Meanwhile, Samyang Group is accelerating their expansion into eco-friendly material business. Samyang Corporation last year developed the country’s first polycarbonate containing more than 90% of post-consumer recycled polycarbonate (PCR PC) material. Additionally, they have signed a supply contract with the fishing net recycling company NETSPA and are developing plastic products for automobile interiors and exteriors, electronic devices, and household goods using recycled plastic pellets from fishing nets, with commercialization on the horizon.

Samyang Innochem, a chemical subsidiary, has completed a production plant for the white bio material "Isosorbide" using corn, and Samyang Packaging is expanding its recycled plastic business, operating a recycling facility for 21,000 tons of PET chips.

Samyang Corporation AM(Advanced Materials) BU(Business Unit) Website

https://samyangep.com/en/index

Source : Samyang Corporation's Eco-Friendly Transparent Flame-Retardant Polycarbonate, Proven Free of Per- and Polyfluoroalkyl Substances

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This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network

Mirrorboard Corp to Showcase 'Snapby AI' at the Innovation Leaders Summit (ILS) in Tokyo.

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SEOUL, South Korea, Dec. 4, 2023 /PRNewswire/ — Mirrorboard Corp, an innovative provider of AI-powered creative solutions, announced its participation in the upcoming Innovation Leaders Summit (ILS), the largest open innovation matching event in Asia, on December 4th. The company will be showcasing its groundbreaking AI stock image service, Snapby AI, which has garnered significant traction since its global launch.

‘Snapby AI’, a next-generation AI stock image service, is poised to revolutionize the traditional stock image market by offering a vast library of over 3 million AI-generated stock images for free. To further enhance its capabilities, Snapby AI now includes a powerful text-to-image generator and a Figma Plug-in, diversifying its content across categories such as animals, objects, nature, and landscapes, catering to the varied needs of content creators.

The success of Snapby AI is evident in its rapid growth, achieving a significant milestone of 100,000 Monthly Active Users (MAU) and 50,000 registered members shortly after its launch. Driven by this momentum, Mirrorboard Corp aims to unveil another innovative system, "The Melting-Pot", at ILS 2023. Designed to tackle the challenges faced by existing stock image providers, The Melting-Pot System is poised to reshape the current market by fostering a more equitable and collaborative environment for photographers and content creators.

The Melting-Pot System directly addresses the concerns of stock image photographers, who have faced reduced revenue sharing and involuntary use of images for AI model training since 2020. This innovative system ensures fair compensation for photographers when their images are used for training and content generation, creating a more balanced and sustainable ecosystem in the era of AI-generated images.  

Moon Haechan, co-founder of Mirrorboard, expressed the company’s commitment to fostering more opportunities for creators and artists. "We are dedicated to establishing a more accessible, reliable, and ethical AI ecosystem where unauthorized license usage is eliminated. In response to concerns about job loss due to recent generative AI innovations, we are committed to creating a more equitable and transparent environment for all stakeholders."

Mirrorboard Corp invites attendees at the ILS to explore the exciting world of Snapby AI and witness the transformative impact of ‘The Melting-Pot’ System.

In 2023, Mirrorboard Corp was selected as a member company of the Global Digital Innovation Network foundation (formerly known as Born2Global Centre) and has benefited from various supportive programs. 

For more information, visit the website https://snapby.ai 

 

Source : Mirrorboard Corp to Showcase 'Snapby AI' at the Innovation Leaders Summit (ILS) in Tokyo.

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This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network

"No Perchlorate, Yes Non-electrolysis"…CJ FNT Introduces Natural Cysteine

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An increasing number of consumers now seek products with a

FlavorNrich™ MASTER C L-Cysteine gives a healthier alternative to the market with growing demands for natural cysteine with no perchlorates

SEOUL, South Korea, Dec. 4, 2023 /PRNewswire/ — CJ Food & Nutrition Tech (CJ FNT) launched an online campaign showcasing its FlavorNrich™ MASTER C L-Cysteine to serve the growing demand for non-electrolytic cysteine.


An increasing number of consumers now seek products with a ‘clean label,’ ‘natural ingredients,’ and also a safer, non-electrolytic cysteine.

Cysteine, one of 20 amino acids, is a key precursor for creating a savory flavor through the Maillard reaction, interacting with reducing sugars to give browned food its distinctive taste. It is typically produced from animal materials through acid hydrolysis or produced by fermentation with synthetic processes such as electrolysis. Cysteine is becoming a crucial part of the future ingredient market as it is used for a wide range of products from pet food to hair care, alternative meat, and future food ingredients. And since it is an essential ingredient for meat-like flavors in animal-free products, its market position will become more solid as the market for alternative meats grows.

Yet, there are still unmet needs for safer non-electrolytic cysteine as more consumers now look for products with "clean label" and "natural ingredients."

Cysteines in the current market are generally produced by "Acid-hydrolysis" with animal feathers or "Electrolysis process"; both are considered "Synthetic" processes that change a material’s original molecular structure, meaning cysteines produced by them are not suitable as "Natural flavor" under the food regulations in the United States and Europe. They also cause concerns over animal welfare and sustainability.

In addition, Some Cysteines produced by the electrolysis process in the market could contain perchlorates more than the permitted level, since perchlorates can be formed by the electrolysis process. High exposure to perchlorates can interfere with iodide uptake into the thyroid gland, disrupting thyroid functions and potentially leading to a reduction in thyroid hormone production. These all lead to growing demands for natural, non-electrolysis cysteines with no perchlorates.

FlavorNrich™ MASTER C L-Cysteine gives an alternative. It is manufactured through only minimal process defined by the US Department of Agriculture (USDA) and the European Union. It is produced by a microbial fermentation process that does not involve electrolysis. As a result, FlavorNrich™ MASTER C is qualified as a "natural flavor" by the standards of the USDA’s Organic Program and the regulations of the US Food and Drug Administration and EU.

"FlavorNrich™ MASTER C L-Cysteine is a fermentation-based, non-electrolysis cysteine made by CJ’s advanced biotechnologies." Said CJ FNT. "It would be a great alternative for our global FMCG customers seeking for natural ingredients for their products." 

About CJ Food & Nutrition Tech (CJ FNT)

CJ Food & Nutrition Tech (CJ FNT) is CJ CheilJedang’s newly established business unit tasked with leading innovations and enhancing wellness in the food and nutritional ingredient market by synergizing CJ’s top-notch food and bio business capabilities. With premium brands for food & nutrition ingredient solutions, CJ FNT leads the trends for natural and plant-based products with more than 200 R&D experts. It understands customer needs for increased efficiency and meeting sustainability market trends. Pursuing growth with clients, partner companies, and the health community, CJ FNT envisions becoming the "global total solution provider" enabling healthier and sustainable lifestyles based on cutting-edge R&D infrastructure.

For more information, visit www.cjfnt.net

Source : "No Perchlorate, Yes Non-electrolysis"…CJ FNT Introduces Natural Cysteine

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This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network

Payton Capital: Request for Expression of Interest – Issue of Debentures (in the form of Notes).

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MELBOURNE, Australia, Dec. 4, 2023 /PRNewswire/ — Payton Capital Ltd (ACN 163 122) is a well-established and reputable fund manager in the Australian Commercial Real Estate (‘CRE’) Debt market. We specialise in ‘Mid-market’ real estate secured loans, ranging from $5 million to $50 million, and we have a proven track record of delivering consistent, risk-adjusted income returns. We pride ourselves on providing a premium investor service with a genuine ESG focus.

Boasting a team of over 50 finance professionals and offices in Victoria, New South Wales, and Queensland, we are continuing to experience significant growth as we capitalise on the strong tailwinds in the private CRE debt sector in Australia. Our assets under management (AUM) have recently surpassed $1.1 billion AUD, with transactions totalling $2.8 billion AUD. Additionally, Foresight Analytics has rated Payton Capital as ‘Very Strong’ as a fund manager.

The Australian CRE Debt market is evolving rapidly and is estimated to be around $450 billion, with private capital managers, including ourselves, contributing $74 billion (Foresight Research, November 2023). Institutional investors find several advantages in the Australian CRE Debt market:

Equity like returns for debt (capital secure) positions Hedge to global volatility, very limited market correlation (alternative fixed interest classification) Protection by virtue of Australian Supply and demand dynamics, growing population and associated forward growth in residential real estate values Stable, monthly income Growing CRE Private Debt market, both by virtue of the market itself and also the increasing share of private to bank (following world trends)

Note Series

Payton Capital, in its capacity as dealer and manager, is pleased to offer to investors an opportunity to subscribe to the Note series as indicated below (the ‘Offer’).  The Offer is made to investors who are qualified as ‘wholesale investors’ as defined in the Corporations Act 2001 (Cth), and a detailed Information Memorandum is available upon request.  Each Note will be issued against a specific security and will be offered individually (through issuance of call notices).  A Supplementary Information Memorandum will be issued for each issue of Notes which will outline the specific terms and returns for that Note. The Offer will be open until it is fully subscribed. Payton Capital reserves the right in its absolute discretion to vary the terms set out below and accept or reject any offer.

Issuer

Payton Select Account Note Series 1 Pty Ltd

Dealer & Manager

Payton Capital Ltd ACN 163 122 478

Amount

Note series will be up to $100 million AUD

Each note will be individual

Timing

This is an open-ended subscription

Rate

Market driven variable rate with a target return of BBSW + a margin of 5% to 6.5% which may also be offered as a fixed rate

Public Offer / Withholding Tax

This notice constitutes an offer to issue debentures or a debt interest for the purposes of, and in accordance with, the "public offer test" in section 128F(3) of the Income Tax Assessment Act 1936 (Cth) (Tax Act), for exemption from Australian interest withholding tax.

Investors will be required to make customary representations and warranties about their status to assist the Issuer to demonstrate compliance with section 128F of the Tax Act, including that the Investor is not an "Associate" (as defined in the Tax Act) of the Issuer.

Restrictions in certain jurisdictions, including Australia

The distribution of this announcement and the offering and sale of the Notes in certain jurisdictions may be restricted by law. This notice does not constitute an offer, invitation or solicitation to participate in the offer and be issued Notes in any jurisdiction where, or to any person or entity to whom, it would be unlawful to make such an offer, invitation or solicitation.

This notice is not a prospectus or disclosure document and it has not been lodged with the Australian Securities & Investments Commission under Chapter 6D of the Corporations Act 2001 (Cth) (Corporations Act). The Offer is only available to domestic and foreign investors who are qualified as "professional investors" or "sophisticated investors" as defined under the Corporations Act (Wholesale Investors). By accepting the Offer, an offeree represents that the offeree is a Wholesale Investor. No Notes will be issued or sold in circumstances that would require the giving of a disclosure document under Chapter 6D of the Corporations Act.

The Notes referred to in this notice have not been, nor will they be, registered under the US Securities Act of 1933, as amended (Securities Act), or with any securities regulatory authority of any state or other jurisdiction of the United States and may not be offered, sold or delivered within the United States or to, or for the account or benefit of, U.S. persons (as defined in Regulation S under the Securities Act) except pursuant to an exemption from, or in a transaction not subject to, the registration requirements of the Securities Act and applicable state securities laws. There will be no public offering of the Notes referred to in this message in the United States.

For expressions of interest and further information please contact:

Attention: David Payton and Craig Schloeffel

Payton Capital | Level 27, 60 City Road, Southbank, VIC, Australia 3006

[email protected] and [email protected]www.payton.com.au

Source : Payton Capital: Request for Expression of Interest – Issue of Debentures (in the form of Notes).

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This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network

Samyang Corporation's Eco-Friendly Transparent Flame-Retardant Polycarbonate, Proven Free of Per- and Polyfluoroalkyl Substances

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SGS, a global inspection and testing company conducts tests for 74 types of per- and polyfluoroalkyl substances Per- and polyfluoroalkyl substances, difficult to be biodegraded and accumulate in the body, cause diseases. Regulatory strengthening trend worldwide Eco-friendly material not using flame retardants. Achieves highest flame-retardant rating, superior chemical resistance and low temperature impact strength compared to standard PC

SEOUL, South Korea, Dec. 4, 2023 /PRNewswire/ — Samyang Corporation targets the global market with its eco-friendly and safety proven transparent flame-retardant polycarbonate material.

Samyang Corporation (CEO Kang Ho-seong) announced on the 4th that its self-developed eco-friendly transparent flame-retardant polycarbonate was tested and found to be free of harmful per- and polyfluoroalkyl substances (PFAS).

Per- and polyfluoroalkyl substances, artificial substances composed of carbon and fluorine, are widely used in electrical and electronic products, food packaging, cosmetics, textiles, and firefighting equipment due to their thermal stability and resistance to water and oil. Termed as "forever chemicals" due to their resistance to natural decomposition, they accumulate in the environment and human body, causing environmental pollution and health issues such as tumors, thyroid disruption, and hormonal imbalances.

Due to these hazards, the United States has already started regulating per- and polyfluoroalkyl substances, and the European Union is pushing for legislation to ban their use, including in harmful chemicals, with other countries also moving toward regulations restricting their use.

Samyang Corporation conducted tests for 74 types of per- and polyfluoroalkyl substances in this test. Key substances tested include △Perfluorooctanesulfonic acid (PFOS), which can cause chronic renal failure, and △Perfluorooctanoic acid (PFOA), known to increase the rate of birth defects and cause various severe diseases such as cancers and thyroid disorders. In addition, tests were conducted for Perfluorohexanesulfonic acid (PFHxS), Perfluoroalkyl carboxylic acids (PFCA), and various per- and polyfluoroalkyl substances, and the results showed no detection of these harmful substances.

SGS, a global inspection and testing company, conducted the detection test for per- and polyfluoroalkyl substances. Established in 1878, SGS operates 2,600 offices and laboratories worldwide, and is highly regarded for its inspection and verification reliability and compliance with international standards. 

Samyang Corporation’s transparent flame-retardant polycarbonate is an eco-friendly material developed by changing the molecular bonding structure based on silicone polycarbonate (Si-PC), without adding halogen-based flame retardants like chlorine and bromine, which produce toxic gases when incinerated.

It overcomes the drawbacks of traditional flame-retardant polycarbonates with decreased transparency and impact strength, and its chemical resistance and low temperature impact strength are superior to regular polycarbonate. The flame-retardant quality is also exceptional, having obtained the highest rating of "V-0" in the UL 94 vertical burn test developed by "UL (Underwriters Laboratories)," a U.S. safety standards development and certification organization. V-0 is awarded only to plastics that self-extinguish within 10 seconds when ignited vertically.

Samyang Corporation plans to expand the use of this material in various industries requiring transparency and flame-retardancy, such as automotive and home appliance exteriors and interiors, sound barriers, and medical device parts, based on its capability to maintain mechanical properties at a similar level to regular polycarbonate even when processed into thin films of about 1 mm thick.

Samyang Corporation’s CEO Kang Ho-seong stated, "The recent environmental pollution and human health issues caused by per- and polyfluoroalkyl substances have become a global concern, leading countries to strengthen regulations on their use. Based on the results of per- and polyfluoroalkyl substance tests, we plan to accelerate the global expansion of transparent flame-retardant polycarbonate, while also leading in the development of eco-friendly and high-functionality materials."

Meanwhile, Samyang Group is accelerating their expansion into eco-friendly material business. Samyang Corporation last year developed the country’s first polycarbonate containing more than 90% of post-consumer recycled polycarbonate (PCR PC) material. Additionally, they have signed a supply contract with the fishing net recycling company NETSPA and are developing plastic products for automobile interiors and exteriors, electronic devices, and household goods using recycled plastic pellets from fishing nets, with commercialization on the horizon.

■ Samyang Corporation AM(Advanced Materials) BU(Business Unit) Website
https://samyangep.com/en/index

Source : Samyang Corporation's Eco-Friendly Transparent Flame-Retardant Polycarbonate, Proven Free of Per- and Polyfluoroalkyl Substances

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