The Highest Award for Exceptional Technology, Engineering, and Science Contributions 
Given by World’s Largest Technical Professional Organization Now Ranks 
Among the Largest Monetary Prizes Globally

For the First Time, Recipient of IEEE 2025 Medal of Honor Award to be Announced at a Press Conference Live-Streamed From New York City Early Next Year

PISCATAWAY, N.J., Sept. 18, 2024 /PRNewswire/ — In a momentous move to recognize the world-changing impact that technology, engineering, and science innovators have on society globally, IEEE, the world’s largest technical professional organization, today announced that starting in 2025, the IEEE Medal of Honor monetary prize will be increased to $2 million. In addition, for the first time, the 2025 IEEE Medal of Honor laureate will be announced at a dedicated press conference in New York City early next year. To help raise visibility for the vast importance of the work that will be honored, the press conference will be live-streamed. Visit https://engage.ieee.org/medal-of-honor to register for the press conference live stream.

"By significantly increasing the IEEE Medal of Honor monetary prize to $2 million we are elevating our recognition of extraordinary individuals and the work they have done to benefit humanity to its rightful place as one of the world’s most prestigious technology-focused prizes and awards," said 2024 IEEE President and CEO Thomas M. Coughlin. "It is a move that also underscores IEEE’s role as a public charity whose mission is to advance technology for the benefit of humanity."

K. J. Ray Liu, Chair of the Ad Hoc Committee on Raising the Prestige of IEEE Awards and 2022 IEEE President and CEO added, "IEEE Medal of Honor laureates dare to envision the new and revolutionary, and make possible what was previously considered impossible. Their seismic accomplishments and positive impact on our world inspires today’s technologists, who stand on their shoulders to continue advancing technology to make the world a better place."

Recipients of the IEEE Medal of Honor Have Advanced Technology and Our World in Revolutionary Ways

Established in 1917, the IEEE Medal of Honor is the highest IEEE award, bestowed for remarkable, society-changing achievements such as the creation of the internet; development of life-saving medical device technologies including the CAT scan, MRI, Ultrasound and Pacemaker; as well as transistors and semiconductors, technologies at the heart of modern electronics and computing. The 2025 IEEE Medal of Honor, as well as additional high-profile IEEE awards, will be presented to recipients at the 2025 IEEE Honors Ceremony, which will for the first time be held in Tokyo, Japan, in April 2025. 

IEEE Medal of Honor laureates include IEEE Life Fellows:

ROBERT E. KAHN — Awarded the 2024 IEEE Medal of Honor for pioneering technical and leadership contributions in packet communication technologies and foundations of the internet. Kahn is President and CEO of the Corporation for National Research Initiatives. While working as a program manager in the U.S. Defense Advanced Research Projects Agency’s information processing techniques office in 1973, Kahn, along with Vinton (Vint) Cerf, designed the Transmission Control Protocol (TCP) and the Internet Protocol (IP). The TCP manages data packets sent over the internet, ensuring they don’t get lost, are received in the proper order, and are reassembled at their destination correctly. The IP manages the addressing and forwarding of data to and from its proper destinations. Together they make up the internet’s core architecture and enable computers to connect and exchange information.

VINTON (Vint) G. CERF – Awarded the 2023 IEEE Medal of Honor for co-creating the internet architecture and providing sustained leadership in its phenomenal growth in becoming society’s critical infrastructure. Cerf is Vice President and Chief Internet Evangelist at Google. He is known as one of the "Fathers of the Internet." With Robert Kahn, he conceived the Transmission Control Protocol/Internet Protocol (TCP/IP) suite, the key technical innovation that permitted the transformation of the original ARPANET into today’s internet. He also formed the Internet Configuration Control Board, which evolved into the Internet Architecture Board, the body responsible today for technical oversight of the internet architecture and standards process.

ASAD M. MADNI – Awarded the 2022 IEEE Medal of Honor for pioneering contributions to the development and commercialization of innovative sensing and systems technologies, and for distinguished research leadership. Madni led the development and commercialization of the GyroChip®, an inexpensive inertial-measurement sensor that was the first such device to be incorporated into automobiles, enabling electronic stability-control (ESC) systems to detect skidding and operate the brakes to prevent rollover accidents. In the five-year period spanning 2011 to 2015, with ESCs being built into all new cars, the systems saved 7,000 lives in the United States alone (U.S. National Highway Traffic Safety Administration). The device went on to serve as the heart of stability-control systems in commercial and private aircraft, U.S. missile guidance systems and traveled to Mars as part of the Pathfinder Sojourner rover.

MILDRED DRESSELHAUS – Awarded the 2015 IEEE Medal of Honor for leadership and contributions across many fields of science and engineering. Emerita professor of physics and materials science at the Massachusetts Institute of Technology (MIT), Dresselhaus was known as the "Queen of Carbon Science" whose research into carbon structures paved the way for the rise of nanotechnology, transforming computing and boosting battery-storage capabilities. Researchers have used these technologies to demonstrate paper-thin batteries, unbreakable touch screens, and terabit-speed wireless communications. Combinations of these carbon structures could yield body armor stronger than Kevlar, ultrathin membranes to filter salt from seawater, and even bionic implants for those with spinal-cord or organ damage. Used as electrodes in batteries or capacitors, graphene and nanotubes in energy storage applications, their charge capacities would exceed traditional batteries. When Dresselhaus began her nearly half-century career at MIT, women were just four percent of the undergraduate student population. Through her leadership, MIT adopted an equal and joint admission process for women and men, and promoted women in science, technology, engineering, and math – now known as STEM.

The IEEE Medal of Honor may be given to an individual or team of up to three who have made exceptional contributions or had extraordinary careers in technology, engineering, and science. Criteria for IEEE Medal of Honor consideration include the significance of the achievement, originality, impact on society, impact on the profession, publications, and patents relating to the achievement.

Learn more about the history of the IEEE Medal of Honor at https://www.ieee.org/ns/periodicals/IEEEMedalofHonor/eBook/index.html

About IEEE Awards

For more than a century, the IEEE Awards Program has served as the world’s top peer-recognition program, acknowledging preeminent leaders and visionaries in science, technology, and engineering advancement. Through the program, IEEE advances its members’ interests by recognizing pivotal contributions in fields of interest to IEEE and to the benefit of society.

The IEEE Awards Board administers the top-level Awards Program, encompassing IEEE Medals, Technical Field Awards, and Recognitions. IEEE’s highest Medals and Recognitions are presented at the IEEE Honors Ceremony. For more information, please visit, or follow IEEE Awards on X|Twitter, Facebook, and LinkedIn.

About IEEE

IEEE is the world’s largest technical professional organization dedicated to advancing technology for the benefit of humanity. Through its highly cited publications, conferences, technology standards, and professional and educational activities, IEEE is the trusted voice in a wide variety of areas ranging from aerospace systems, computers, and telecommunications to biomedical engineering, electric power, and consumer electronics. Learn more at https://www.ieee.org.

Contact:
Monika Stickel
+1 732 562 6027
[email protected]

Francine Tardo
+1 732 465 5865
[email protected]

Source : PRESTIGIOUS IEEE MEDAL OF HONOR PRIZE IS INCREASED TO $2 MILLION

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Annual family office survey highlights that family offices in Asia Pacific expect stronger portfolios gains in 2025  Asia Pacific leads the way in family office best practices and leadership transition readiness 

SINGAPORE, Sept. 18, 2024 /PRNewswire/ — Citi Private Bank’s Global Family Office Group today released the results of its 2024 Family Office Survey, unveiling trends among family offices in Asia Pacific and globally. Results show that family offices in Asia Pacific are leading the way in deploying more capital into public equity and increasing direct investing.

The annual study provides a rare glimpse into the thinking and behaviors of family office clients, some of the most sophisticated investors. In its fifth edition, the survey captures the investment sentiment, portfolio positioning, family governance and best practices of family office clients in 2024. It received a record number of respondents this year, making it the most global and comprehensive survey of its kind, with 21% of respondents from Asia Pacific.

"We are thrilled to share this year’s survey findings, which offer an inside look into the investments and priorities of some of the world’s most diverse and sophisticated family offices," says Hannes Hofmann, Head of the Global Family Office Group at Citi Private Bank. "In the last two years, we have seen the number of respondents grow from 126 to 338 across the globe, indicating an increased need for the unique insights into the top challenges and opportunities family offices face today. The wide-ranging questions cover the most topical global issues, revealing important shifts in the concerns and interests of respondents. We look forward to continuing our close partnership with family offices to provide access to all areas of Citi that support the ambitious goals and needs of the world’s most global and sophisticated investors."

ASIA PACIFIC HIGHLIGHTS

In addition to global themes and discoveries, several key findings emerged from Asia Pacific:

Investment activity, sentiments and preference across Asia Pacific

68% of family offices reported increased allocation into public equity – the highest percent relative to other regions. Family offices said they were positive on the outlook for global developed equities (48%), direct private equity (49%) and private equity funds (48%). Direct investing activity was highest in Asia Pacific, with 69% of respondents reporting increased and significantly increased activity. Results show an interest in a broad range of activities across the M&A spectrum: strategic acquisitions (20%), joint ventures (23%), divestitures (9%) and mergers (14%). 63% of respondents expect their portfolios to increase by 10% or more in the coming year, the highest percent relative to other regions.

Family office focus areas and challenges across Asia Pacific

Family offices are leading in best practices such as separating the family office from the family business (75%) and having a leadership succession plan (51%).  74% of respondents said they were well or very well prepared for leadership transitions. Cost (45%) and regulatory compliance (48%) are seen as the main challenges for family offices in Asia Pacific, which may be because the family office industry is relatively new and developing rapidly in the region. There is also more outsourcing to external service providers in the region.

"The family office industry in Asia continues to grow and evolve rapidly – becoming ever more complex with time," says Bernard Wai, Asia Pacific Head, Global Family Office Group, Citi Private Bank. "Citi’s global footprint and connectivity across the family office network can help Asian family offices learn and adopt best practices faster to achieve their financial and family office goals in the long run."

The 2024 Global Family Office Survey Insights Report also revealed a shift in portfolio allocations. Public equities and fixed income saw their weightings rise from 22% to 28% and 16% to 18%, respectively. Private equity also dipped from 22% to 17%, which may have been accentuated by valuations taking longer to adjust upward compared to those of public equities. 

"Our family office clients are increasingly becoming more global as they seek to create and preserve wealth amidst new market challenges and opportunities," says Ida Liu, Head of Citi Private Bank. "As interest rates evolve and geopolitical challenges persist, ultra-high net worth investors and their families are putting cash to work and shifting their portfolios toward public and private equity. Family offices are focused on the future as they navigate evolving markets worldwide."

GLOBAL THEMES

Family offices are putting their cash to work by making significant portfolio shifts from liquid resources to fixed income, public and private equity. Continued optimism among family offices around the outlook for portfolio performance over the next twelve months, with 97% of respondents expecting positive returns. The future path of interest rates is the top concern followed by geopolitical issues – such as US-China relations and the conflict in the Middle East. Family offices are growing their portfolio exposure to artificial intelligence – which likely contributed to strong returns over the last year. However, the adoption of this technology into family office operations is lagging. Asset preservation and preparing the next generation for future responsibilities are families’ top concerns. Meeting family members’ expectations is regarded as family offices’ top challenge.

This year’s survey was initiated during Citi Private Bank’s ninth annual Family Office Leadership Program held in June 2024. The survey was subsequently released to Citi Private Bank’s global family office clients for input, with 50 questions aimed to capture the investment sentiment, portfolio positioning, family governance and best practices of family office clients. It drew responses from 338 participants who were included in this report.

About Citi
Citi is a preeminent banking partner for institutions with cross-border needs, a global leader in wealth management and a valued personal bank in its home market of the United States. Citi does business in more than 180 countries and jurisdictions, providing corporations, governments, investors, institutions and individuals with a broad range of financial products and services.

Additional information may be found at www.citigroup.com | X: @Citi | LinkedIn: www.linkedin.com/company/citi | YouTube: www.youtube.com/citi | Facebook: www.facebook.com/citi  

Source : Family Offices in Asia Pacific are Investing More in Public Equity and Fixed Income, Bullish on Private Equity: Citi Private Bank Survey

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SHENZHEN, China , Sept. 18, 2024 /PRNewswire/ — TerraMaster, a leading brand in home and enterprise storage solutions, has recently announced the launch of 9 new NAS models, all equipped with its latest TOS 6 operating system. This lineup includes two 8-bay all-flash NAS models specifically designed for high-performance needs. All new products were officially launched on September 19, 2024, on the TerraMaster official website and various global e-commerce platforms. 

TerraMaster 2024 Fall New Product Lineup

Comprehensive Range

The new TerraMaster product series covers a wide spectrum of users, from individual consumers and SMBs to high-end devices for business and enterprise sectors, fully addressing different needs.

8-Bay All-Flash NAS

The two 8-bay all-flash NAS models, F8 SSD and F8 SSD Plus, are designed specifically for creative and media professionals. The F8 SSD Plus features an Intel 8-core, 8-thread CPU, supports 4K hardware decoding, AES NI hardware encryption, and comes with 16GB DDR5 and a 10GbE Ethernet port. It is the most powerful compact 8-bay NAS in the industry.

New 10GbE NAS Series

The new 10GbE NAS series is tailored for home users and SMB (small and medium-sized business) environments, featuring Intel’s latest 12th-generation processor technology. The F4-424 Max and F6-424 Max models are equipped with a 12th-generation Intel Core i5 processor, offering a robust configuration of 10 cores and 12 threads.

4 Backup All-in-One Models

The new backup all-in-one models, designed specifically for enterprise backup needs, include two tower models—T9-500 Pro and T12-500 Pro—and two rackmount models—U8-500 Plus and U12-500 Plus. Each model is equipped with a 12th-generation Intel Core i7 processor with 10 cores and 12 threads, and 16GB of expandable DDR5 memory.

New TOS 6 System

TOS 6 features a completely redesigned user interaction model and introduces a comprehensive BBS commercial backup suite. It also includes a full upgrade of its security mechanisms, with innovative features such as TRAID+, SPC-Security Privacy Control, ACL-13 Permissions, OTP Two-Factor Authentication, HyperLock WORM, and system snapshot TFSS. Notably, TOS 6 offers full compatibility with Ubuntu root file systems, making the operating system more familiar and easier to maintain.

Time-Limited Offer

On September 19, 2024, the first 100 buyers will receive a $100/€100/£100 time-limited discount.

More information, please visit:

https://support.terra-master.com/2024_fall_newlineup/ 

Amazon Links: US, UK, CA, AU, DE, IT, RU, FR, ES,

TerraMaster Social Media: Facebook, Twitter, LinkedIn, YouTube, Tiktok

Source : TerraMaster Unveils 9 New NAS Models with TOS 6 System

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This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network

LONDON, Sept. 18, 2024 /PRNewswire/ — Polus Capital Management ("Polus"), a leading investment management firm specialising in alternative credit strategies, today announces that it has secured a capital commitment for its Special Situations strategy from a wholly owned subsidiary of Abu Dhabi Investment Authority (ADIA). Following the commitment, Polus’ Special Situations strategy has approximately $5 billion of assets under management[i].

Polus’ Special Situations strategy focuses primarily on secondary investments in bonds and loans as part of opportunistic, stressed or distressed situations arising from idiosyncratic or cyclically driven dislocations to corporate enterprise values or hard asset values. Polus’ Special Situations team has been working together for over ten years, during which time it has developed a differentiated and proven track record.

ADIA’s investment is a strong endorsement of the high quality and attractive characteristics of Polus’ Special Situations strategy and further adds to Polus’ predominantly institutional investor base which includes pension funds, insurance companies, endowments, foundations, sovereign wealth funds and family offices.

Nicholas Chalmers, Chief Executive Officer of Polus Capital Management, said, "ADIA’s capital commitment reflects the growing strength and success of Polus’ diversified alternative credit platform. We look forward to the ongoing development of our business while continuing to prioritise the delivery of compelling risk-adjusted returns as we navigate opportunities in credit markets throughout the cycle."

Robert Dafforn, Chief Investment Officer of Opportunistic Credit at Polus Capital Management, said, "We are delighted to welcome ADIA’s subsidiary as an investor and are increasingly excited about the opportunity set for our Special Situations strategy. We believe the coming years will prove especially favourable for our differentiated investment approach and rewarding for our investors."

Hamad Shahwan Aldhaheri, Executive Director of the Private Equities Department at ADIA, said, "Polus is one of the leading alternative credit managers in Europe with a large, experienced team, a differentiated strategy and a strong track record. We look forward to capitalising on a growing market opportunity through our capital commitment in Polus, which has built deep expertise in providing bespoke, innovative solutions in a range of situations."

About Polus Capital Management

Polus Capital Management ("Polus") is an investment management firm specialising in alternative credit strategies. Following the commitment, Polus has approximately $11 billion in assets under management[ii] and invests across the capital structure and liquidity spectrum, focusing on three complementary strategies: Leveraged Credit, Special Situations and Structured Credit. Polus has offices in London and New York.

For more information: www.poluscapital.com 

About Abu Dhabi Investment Authority 

Established in 1976, ADIA is a globally diversified investment institution that prudently invests funds on behalf of the Government of Abu Dhabi through a strategy focused on long-term value creation.

For more information: www.adia.ae 

Media Enquiries 

Greenbrook – Rob White / Ksenia Galouchko
[email protected]
Tel: +44 (0) 20 7952-2000  

[i] AUM refers to assets under management and advice and includes committed but uncalled capital across various vehicles. AUM figures as at 18 Sep 2024 and are subject to rounding and FX fluctuations.

[ii] AUM refers to assets under management and advice and includes CLO vehicles managed by Cairn Loan Investments LLP ("CLI I") and Cairn Loan Investments II LLP ("CLI II"). CLI I and CLI II are not affiliates of each other nor of Polus, but Polus established them and provides them with seconded portfolio managers and support services. AUM includes committed but uncalled capital across various vehicles. AUM figures as at 18 Sep 2024 and are subject to rounding and FX fluctuations.

Source : Polus Capital Management Secures ADIA Commitment for Special Situations Strategy

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This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network

Moomoo Singapore received the prestigious award at the SIAS Investors’ Choice Awards Recognises Moomoo Singapore’s commitment to democratise investing for all Holds added significance for Moomoo Singapore as we hit more than 1 million users

SINGAPORE, Sept. 18, 2024 /PRNewswire/ — Moomoo Financial Singapore Pte. Ltd. ("Moomoo Singapore") has been named the Best Retail Broker in Singapore by the Securities Investors Association (Singapore) ("SIAS") — for the second consecutive year. 

Mr Gavin Chia, CEO of Moomoo Singapore, received the prestigious award at the SIAS Investors’ Choice Awards Dinner on Tuesday, 17 September 2024. The event was graced by Guest-of-Honour, Mr Tharman Shanmugaratnam, President of Singapore, as well as Mr Goh Chok Tong, Emeritus Senior Minister.

"We are honoured to be recognised as the Best Retail Broker in Singapore for the second year running. This prestigious accolade recognises our unwavering commitment to be the leading broker of choice for retail investors in Singapore, and is testament to our dedication to provide an exceptional investment platform for all," Chia said.

"Our successful defence of the Best Retail Broker award this year has added meaning and significance for Moomoo Singapore, as we achieved the one million user milestone in Singapore earlier this year. With 1 in 3 Singapore residents now using our platform in pursuit of their investment goals, this award reaffirms our growing reputation as the investment platform of choice for those in Singapore," he added.

The Best Retail Broker Award caps off a strong quarter for Moomoo Singapore, and follows closely on the heels of two other accolades  — the Investment Tech of the Year Award at the Asia Fintech Awards 2024, as well as the Investment Product Innovation of the Year (Singapore), awarded as part of the Asian Banking & Finance Retail Banking Awards 2024.

"The numerous accolades we have received reflect the dedication we have invested in building and improving the moomoo platform. We remain committed to further strengthening our technology capabilities to ensure we provide our clients with the most effective tools to support their success in their investment journeys."

Slew of Achievements

Today, moomoo offers a wide range of tech features on its platform. They include:

Industry Chain: Helps investors gain an intuitive and comprehensive understanding of upstream and downstream industries by mapping the industrial chains of HK stocks, US stocks, and A-shares with its knowledge mapping algorithm. Institutional Tracker: Investors can see their favourite institutions such as Berkshire, Soros, or Ark Investment, as well as the stocks that these institutions are holding. This allows them to mimic the movements of the trading strategies of these institutions. Advanced Stock Screener: Contains more than 100 advanced stock screening indicators, making it the most comprehensive stock screener on the market with low latency and real-time calculations. Patented charting tools: With 38 drawing tools and more than 60 technical indicators, as well as real-time data, users can draw lines and shapes on charts, facilitating price movement analysis, pattern recognition, and identification of potential market opportunities from the convenience of their mobile devices — anytime and anywhere.

"While our tech capabilities have been crucial to our success over the years, our rapid growth over the years has been made possible by our deep understanding of the retail investment community in Singapore. Through our frank conversations with retail investors at roadshows and offline activities, we have gained deep insights into their investment objectives, and accordingly tailored our offerings in response to their needs. Such engagement with the retail community will continue to be at the heart of what we do, even we work towards the next significant milestone for Moomoo Singapore," Chia said.

"This is deeply aligned with the objectives of SIAS, whose unrelenting commitment to protect the rights of retail investors in Singapore has been a role model for all. We will continue to work with SIAS to ensure that the voice of retail investors is heard, and to raise the standard of investor education in Singapore. On this occasion, I would like to wish SIAS a very happy 25th anniversary," he added.

About Moomoo Singapore

Moomoo Financial Singapore Pte. Ltd. (Moomoo Singapore) is an award-winning advanced financial technology company transforming the investing experience through our digitalised brokerage and wealth management platform – moomoo. Moomoo enhances the user experience with market data, news, and powerful analytical tools. Moomoo also embeds a unique digitalised investment community to connect all users, investors, companies, analysts, media and key opinion leaders.

In Singapore, Moomoo Financial Singapore Pte. Ltd. (www.moomoo.com/sg) offers investment products for trading via the moomoo platform, and it is a capital markets services license holder regulated by the Monetary Authority of Singapore (Licence No. CMS101000), Major Payment Institution (Licence No. PS20200617) holder with the Exempt Financial Adviser Status.  In April 2024, Moomoo Singapore reached the 1 million users milestone in Singapore.

Moomoo Private Wealth offers bespoke investment strategies for HNW and institutional clients. Backed by its cutting-edge technology platform, Moomoo Private Wealth offers a portfolio of innovative investment products that rival that of traditional private banks, and has been recognised by Asia Banking and Finance for its product excellence. Visit us at: https://www.moomoo.com/sg/private-wealth

Our achievements include the Investment Tech of the Year award at the 2024 Asia Fintech Awards and the SIAS Best Retail Broker 2024.

Source : Moomoo Singapore is Best Retail Broker in Singapore for the second year running

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BARCELONA, Spain, Sept. 18, 2024 /PRNewswire/ — The highly anticipated 2024 European Society for Medical Oncology (ESMO) Annual Congress has taken place in Barcelona, Spain. As one of the most influential annual gatherings in oncology, this congress brings together leading cancer experts and researchers from around the globe, showcasing the latest advancements in the field and providing high-quality educational and networking opportunities for oncology professionals.

Biosyngen, an innovative biotechnology company specializing in immune cell therapies, is proud to present Phase I clinical data for its pioneering CAR-T therapy targeting Epstein-Barr virus (EBV) antigens for the treatment of nasopharyngeal carcinoma (NPC).

From left to right: Ma Yuxiang, Associate chief physician in Phase I Unit in Clinical Trial Center and PhD in Oncology, Sun Yat-sen University Cancer Center; Professor Zhao Hongyun, Director in Phase I Unit in Clinical Trial Center and Deputy director in Clinical Research, Sun Yat-sen University Cancer Center; Statham Liu, Senior R&D Scientist, Biosyngen

Abstract Title

Safety and efficacy of a novel CAR-T cell therapy (BRG01) targeting the Epstein-Barr Virus envelope glycoprotein in advanced metastatic nasopharyngeal cancer (NPC) patients 

Abstract No.:

899P

The presentation highlights that the Phase I clinical trial of BRG01 has successfully completed dose-limiting toxicity (DLT) observations and efficacy evaluations in nine patients, all diagnosed with advanced NPC. Notably, 100% of participants had previously undergone platinum-based chemotherapy and failed at least one immune checkpoint inhibitor, including PD-1 antibodies, while 45% had also failed treatment with antibody-drug conjugates (ADCs).

Preliminary data indicates that BRG01 demonstrates exceptional safety and preliminary efficacy. In terms of safety, no cases of dose-limiting toxicity, neurotoxicity, grade 2 or higher cytokine release syndrome, or treatment-related death were observed. The most common grade 3 adverse events were transient leukopenia related to the lymphodepletion regimen.

In terms of efficacy, disease control and response rates exhibited a clear dose-dependent relationship. Higher doses led to more significant effects, with 75% of patients experiencing a sustained reduction in tumor burden and diminished metabolic activity, and several lesions achieving complete response (CR) with 100% tumor reduction.

75% of patients experiencing a sustained reduction in tumor burden and diminished metabolic activity, and several lesions achieving complete response (CR) with 100% tumor reduction.

Patients treated with BRG01 have shown a progression-free survival exceeding six months post-infusion, demonstrating significantly extended antitumor effects compared to the current standard treatment, checkpoint inhibitors like PD-1 antibodies.

Patients treated with BRG01 have shown a progression-free survival exceeding six months post-infusion, demonstrating significantly extended antitumor effects compared to the current standard treatment, checkpoint inhibitors like PD-1 antibodies.

Additionally, BRG01 exhibited remarkable antiviral efficacy, with a significant reduction in EBV viral load in peripheral blood to normal levels post-infusion.

BRG01 exhibited remarkable antiviral efficacy, with a significant reduction in EBV viral load in peripheral blood to normal levels post-infusion.

Professor Zhang Li, the principal investigator (PI) of this clinical trial, and Director of the Phase I Unit at Sun Yat-sen University Cancer Center, stated, "BRG01 has the potential to be a ‘first-in-class’ T cell therapy for EBV-positive tumors. Its unique mechanism and robust Phase I data instill confidence in its Phase II clinical performance. We look forward to establishing its clinical efficacy through further studies, offering new hope for more patients."

As previously reported, BRG01 has received regulatory approvals for Phase II clinical trials in July (China) and August (U.S.) with patient enrollment now underway.

These data not only underscore the potential of BRG01 in treating cancer but also highlights its dual advantages in antiviral therapy, establishing a solid foundation for future clinical applications. This is likely a key factor in the Center for Drug Evaluation, NMPA and FDA’s decision to advance BRG01 to Phase II trials.

BRG01 is an autologous T cell immunotherapy that expresses a chimeric receptor targeting EBV antigens through genetic modification. It represents Biosyngen’s global innovation in next-generation CAR-T cell therapy specifically for EBV. The therapy received clinical trial approval from the CDE in December 2022 and the FDA in February 2023. Subsequently, it was granted orphan drug designation (ODD) and fast track designation (FTD) by the FDA in June and July 2023, respectively, marking rapid simultaneous progress in both the U.S. and China.

Biosyngen’s commitment to solid tumor cell therapies extends beyond BRG01. The company is emerging as a biotech leader with a portfolio that includes CAR-T, TCR-T, and TIL therapies targeting both solid and hematologic tumors. All related product pipelines have achieved simultaneous regulatory submissions and approvals in both the U.S. and China, covering various solid tumors, including lung and liver cancer.

Regarding the initial release of BRG01’s Phase I clinical data, Dr. Michelle Chen, co-founder and CEO of Biosyngen, stated, "BRG01 is the result of years of hard work by our team and a testament to the recognition of our core technology and research capabilities. Biosyngen is committed to developing innovative drugs that address unmet clinical needs in oncology. In the future, we will continue to increase our R&D investments and expedite the clinical trial and commercialization processes for BRG01, providing more effective and accessible treatment options for patients worldwide."

With Biosyngen’s efficient execution and rapid research advancements, we have reason to be optimistic about achieving further clinical breakthroughs in solid tumor cell therapies in a shorter timeframe, bringing new hope to patients.

Source : Biosyngen's first-in-class CAR-T asset targeting solid tumors has entered pivotal phase II trial, Phase I trial data debut at ESMO 2024 Annual Congress

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80% of Global Commercial Fleet Leaders Surveyed Set Goal for 25% EVs by 2030, Latest Frost & Sullivan Insights Reveal

LONDON, Sept. 18, 2024 /PRNewswire/ — Conducted by Frost & Sullivan and commissioned by WEX (NYSE: WEX), a new report provides key insights for organisations managing mixed-energy fleets across Europe, North America, and Asia-Pacific.

The study underscores the rapid progress in fleet electrification. While EV adoption rates vary by business and fleet type, most fleet managers expect a significant increase in EVs to enter their fleets over the next five years. Almost half of those surveyed stated that 50% or more of their fleet would consist of EVs by 2030. 

The 2024 global survey, "The Commercial EV Transition: Global Insights on a Mixed-Energy Fleet Future," offers comprehensive insights to help organisations navigate and capitalise on the shift to electrification across Europe, North America, and Asia-Pacific.

The transition to a mixed-energy fleet – which integrates both EVs and internal combustion engine (ICE) vehicles – will take time, but fleet managers are working actively to accelerate the process. EV adoption rates will vary significantly depending on factors such as the region, industry, and organisational scale, making it crucial to understanding the underlying dynamics that can unlock opportunities for more sustainable and cost-efficient operations.

"The study demonstrates that there is still high ambition to integrate EVs into fleet operations, not just to meet sustainability targets but to enable more cost-effective operations, however, achieving this transition presents significant challenges," said Dr. Jose Pereira, Director in the Frost & Sullivan’s Mobility Advisory practice.

"This report’s findings demonstrate that fleet managers continue to seek guidance from trusted experts and partners to determine the best approach for their needs," he added. "A key issue is understanding how to develop an optimal EV adoption roadmap that balances the initial investments in vehicle and charging infrastructure costs with the operational savings opportunities that come from lower electric fuel costs, reduced servicing and extended vehicle service life, as well as the improved driver satisfaction and wellbeing from quieter and smoother vehicles"

As fleet managers begin to manage a mix of traditional and electric vehicles, they face new challenges such as keeping site EV infrastructure online, optimising energy costs through improved scheduling and route planning, and managing payments from various charging locations. This will necessitate adjustments to existing fleet management and payment systems to ensure smooth operations and a viable overall business case.

The report also addresses broader industry implications, identifying the top three challenges for fleet operators: fuel costs (67%), operational expenses (66%), and profit margins (59%). These challenges reflect fleet managers’ pressures to manage expenses and maintain profitability while transitioning to new technologies and sustainable practices.  

About the Fleet Study

These are the findings of a Frost & Sullivan study commissioned by WEX between February-March 2024, based on interviews with mixed-energy fleet operators about their journey towards electrification, representing over 500 organisations across seven markets: 273 respondents in Europe,110 respondents in the United States, and 120 respondents in two Asia-Pacific markets in Asia-Pacific (120 respondents).

A complimentary copy of the study is available for download here. Market-level insights can be viewed for the United Kingdom, Benelux (comprised of Belgium, the Netherlands, and Luxembourg), France, Germany, Italy, the United States, Australia, and New Zealand.  

About Frost & Sullivan

Frost & Sullivan, the growth pipeline company, enables clients to accelerate growth and achieve best-in-class positions in growth, innovation, and leadership. The company’s Growth Pipeline as a Service provides the CEO and the CEO’s Growth Team with transformational strategies and best-practice models to drive the generation, evaluation, and implementation of powerful growth initiatives. Frost & Sullivan leverages over 60 years of experience in partnering with Global 1000 companies, emerging businesses, and the investment community from more than 40 offices on six continents.

To engage with our growth experts for more information, click here

Contact:

Kristina Menzefricke
Marketing & Communications
Global Customer Experience, Frost & Sullivan
[email protected]
+44 (0)20 331 01228

Source : Electrified Fleet Adoption Surges Despite Slowing EV Demand in Passenger Market

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